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Titolo:
Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery
Autore:
Al-Sahli, W; Ahmad, H; Kheradmand, F; Connolly, C; Docherty, JR;
Indirizzi:
Royal Coll Surg Ireland, Dept Physiol, Dublin 2, Ireland Royal Coll Surg Ireland Dublin Ireland 2 Dept Physiol, Dublin 2, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 422, anno: 2001,
pagine: 169 - 174
SICI:
0014-2999(20010622)422:1-3<169:EOMONC>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
COCAINE; MDMA; ECSTASY; BRAIN; 3,4-METHYLENEDIOXYMETHAMPHETAMINE; HUMANS; PHARMACOKINETICS; HEART;
Keywords:
MDMA (methylenedioxymethamphetamine); cocaine; ventricle; mesenteric artery, small; noradrenaline;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Docherty, JR Royal Coll Surg Ireland, Dept Physiol, 123 St Stephens Green,Dublin 2, Ireland Royal Coll Surg Ireland 123 St Stephens Green Dublin Ireland 2
Citazione:
W. Al-Sahli et al., "Effects of methylenedioxymethamphetamine on noradrenaline-evoked contractions of rat right ventricle and small mesenteric artery", EUR J PHARM, 422(1-3), 2001, pp. 169-174

Abstract

We have compared the effects of methylenedioxymethamphetamine (MDMA) and cocaine on contractions to noradrenaline in I Hz paced rat right ventricularstrips, and in rat small mesenteric artery and aorta. Noradrenaline increased the force of contraction of 1 Hz paced ventricular strips with a pD(2) (- log EC50) of 5.64 +/- 0.07. Both cocaine (10 muM) and MDMA (10 muM) significantly increased the potency of noradrenaline to 6.31 +/- 0.11 and 6.42 /- 0.13, respectively. However, in the presence of cocaine (10 muM) which increased the potency of noradrenaline to 6.78 +/- 0.15, MDMA (10 muM) no longer increased the potency of noradrenaline (pD(2) of 6.78 +/- 0.32). Likewise, following chemical sympathectomy, MDMA failed to increase the potencyof noradrenaline. The potency of the agonist isoprenaline, which is not a substrate for the noradrenaline transporter, was not increased by either cocaine or MDMA. In rat small mesenteric artery, but not aorta, MDMA and cocaine significantly increased the potency of noradrenaline, but in the presence of cocaine, MDMA had no further effect. Hence, MDMA shares with cocaine an ability to potentiate the actions of noradrenaline, an action in the case of MDMA which may involve competitive blockade of the noradrenaline transporter, rather than simply displacement of noradrenaline. Since cocaine is linked to an increased incidence of myocardial infarction, these results may have implications in terms of cardiac morbidity of MDMA. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:26:48