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Titolo:
Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats
Autore:
Glick, SD; Maisonneuve, IM; Dickinson, HA; Kitchen, BA;
Indirizzi:
Albany Med Coll, Ctr Neuropharmacol & Neurosci, MC136, Albany, NY 12208 USA Albany Med Coll Albany NY USA 12208 Neurosci, MC136, Albany, NY 12208 USA
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1-3, volume: 422, anno: 2001,
pagine: 87 - 90
SICI:
0014-2999(20010622)422:1-3<87:CEODAD>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA ANTAGONIST; DISEASE; SITES; BRAIN;
Keywords:
dextromethorphan; dextrorphan; morphine; methamphetamine; nicotine; drug addiction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Glick, SD Albany Med Coll, Ctr Neuropharmacol & Neurosci, MC136, 47 New Scotland Ave, Albany, NY 12208 USA Albany Med Coll 47 New Scotland Ave AlbanyNY USA 12208 2208 USA
Citazione:
S.D. Glick et al., "Comparative effects of dextromethorphan and dextrorphan on morphine, methamphetamine, and nicotine self-administration in rats", EUR J PHARM, 422(1-3), 2001, pp. 87-90

Abstract

The effects of dextromethorphan and its metabolite dextrorphan on morphine, methamphetamine and nicotine self-administration and on responding for a nondrug reinforcer (water) were assessed in rats. Both dextromethorphan anddextrorphan decreased morphine self-administration at 10-30 mg/kg, s.c., decreased methamphetamine self-administration at 20 and 30 mg/kg, s.c., and decreased nicotine self-administration at 5-30 mg/kg, s.c.; doses of both drugs less than 40 mg/kg, s.c. did not affect responding for water. The equal potencies of dextromethorphan and dextrorphan suggest mediation of these effects by a non-NMDA receptor mechanism, possibly involving blockade of alpha3 beta4 nicotinic receptors. The results also suggest that dextromethorphan should be tested extensively as a potential treatment for diverse populations of drug-abusing patients. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 11:41:43