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Titolo:
Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats
Autore:
Kozela, E; Danysz, W; Popik, P;
Indirizzi:
Polish Acad Sci, Inst Pharmacol, PL-31343 Krakow, Poland Polish Acad Sci Krakow Poland PL-31343 harmacol, PL-31343 Krakow, Poland Merz & Co Gmbh & CO, Dept Pharmacol, Frankfurt, Germany Merz & Co Gmbh & CO Frankfurt Germany ept Pharmacol, Frankfurt, Germany
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 423, anno: 2001,
pagine: 17 - 26
SICI:
0014-2999(20010629)423:1<17:UNRAPM>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID ANTAGONISTS; PERIAQUEDUCTAL GRAY; ACUTE TOLERANCE; DOUBLE-BLIND; DEXTROMETHORPHAN; ANALGESIA; MK-801; INHIBITION; GLUTAMATE; DEXTRORPHAN;
Keywords:
morphine; opiate; antinociception; NMDA receptor antagonist; memantine; dextromethorphan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Kozela, E Polish Acad Sci, Inst Pharmacol, 12 Smetna St, PL-31343 Krakow, Poland Polish Acad Sci 12 Smetna St Krakow Poland PL-31343 kow, Poland
Citazione:
E. Kozela et al., "Uncompetitive NMDA receptor antagonists potentiate morphine antinociception recorded from the tail but not from the hind paw in rats", EUR J PHARM, 423(1), 2001, pp. 17-26

Abstract

We investigated the effects of pretreatment with low-affinity, uncompetitive NMDA receptor antagonists on morphine-induced antinociception in rats using the same intensity of thermal stimulus applied to the tail and the paws. Similar baseline responses to thermal stimuli of the same intensity were recorded from tails and hind paws. However, morphine produced equal antinociception from the tail and hind paw when used at doses of 2.5 and 6 mg/kg, respectively. These doses were used in further experiments. Thirty minutes before morphine, rats were administered the NMDA receptor antagonists dextromethorphan (2.5-30 mg/kg), memantine (2.5-15 mg/kg) and MRZ 2/579 (1-arnino-1,3,3,5,5-pentarnethyl-cyclohexane HCl) (1.25-10 mg/kg). All three compounds significantly and dose-dependently potentiated morphine-induced antinociception recorded from the tail. However, none of these NMDA receptor antagonists affected morphine antinociception recorded from the paw. These findings suggest that low-affinity NMDA receptor antagonists modulate differently morphine antinociceptive activity recorded from the tail and hind paws. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:21:00