Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Evaluation of the Intelisite capsule to deliver theophylline and frusemidetablets to the small intestine and colon
Autore:
Clear, NJ; Milton, A; Humphrey, M; Henry, BT; Wulff, M; Nichols, DJ; Anziano, RJ; Wilding, I;
Indirizzi:
Pfizer Ltd, Cent Res, Pharmaceut Res & Dev, Sandwich CT13 9NJ, Kent, England Pfizer Ltd Sandwich Kent England CT13 9NJ andwich CT13 9NJ, Kent, England Pfizer Ltd, Cent Res, Early Clin Res Grp, Sandwich CT13 9NJ, Kent, EnglandPfizer Ltd Sandwich Kent England CT13 9NJ andwich CT13 9NJ, Kent, England Pfizer Inc, Cent Res, Biometr, Groton, CT 06340 USA Pfizer Inc Groton CT USA 06340 c, Cent Res, Biometr, Groton, CT 06340 USA Pharmaceut Profiles, Nottingham NG11 6JS, England Pharmaceut Profiles Nottingham England NG11 6JS ingham NG11 6JS, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 4, volume: 13, anno: 2001,
pagine: 375 - 384
SICI:
0928-0987(200107)13:4<375:EOTICT>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACEUTICAL DOSAGE FORMS; GASTROINTESTINAL-TRACT; DIFFERENT REGIONS; HEALTHY-SUBJECTS; RESIDENCE-TIME; DRUG DELIVERY; ABSORPTION; TRANSIT; PERMEABILITY; FUROSEMIDE;
Keywords:
non-invasive regional drug delivery; intestinal and colonic drug absorption theophylline; frusemide;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Clear, NJ Pfizer Ltd, Cent Res, Pharmaceut Res & Dev, Ramsgate Rd, Sandwich CT13 9NJ, Kent, England Pfizer Ltd Ramsgate Rd Sandwich Kent England CT139NJ t, England
Citazione:
N.J. Clear et al., "Evaluation of the Intelisite capsule to deliver theophylline and frusemidetablets to the small intestine and colon", EUR J PH SC, 13(4), 2001, pp. 375-384

Abstract

The objective of the research was to establish the capability of the Intelisite capsule to deliver the probe drugs, theophylline and frusemide, in the form of split immediate release (IR) tablets, to the small intestine and colon. The two probe drugs were administered together in an open, random, three-way crossover study in eight healthy volunteers, comparing absorption following Intelisite: delivery in the small bowel and colon to conventionalIR dosing. Gamma scintigraphy was employed to monitor the gastrointestinaltransit and activation of the Intelisite capsule. Standard pharmacokineticparameters, and the percentage remaining in the capsules post defecation were determined. The Intelisite capsule was well tolerated in human volunteers and successfully activated on 15/16 occasions. Pharmacoscintigraphy showed internal marker release from the Intelisite capsule to be similar to 10-fold faster in the small intestine than in the colon. Theophylline and frusemide were both well absorbed following Intelisite activation in the small intestine, whereas complete colonic absorption was only observed in 1/7 subjects for theophylline, and 0/7 subjects for frusemide. The probe drugs were successfully delivered in particulate form from the Intelisite capsule inthe small intestine and produced expected pharmacokinetic profiles. However drug release in the colon was incomplete and variable possibly due to: low water content, poor mixing, and a high loading dose. (C) 2001 Published by Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:23:08