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Titolo:
A scintigraphic study to investigate the potential for altered gut distribution of loperamide from a loperamide-simethicone formulation in man
Autore:
Conner, AL; Wray, H; Cottrell, J; Wilding, IR;
Indirizzi:
Pharmaceut Profiles Ltd, Nottingham NG11 6JS, England Pharmaceut Profiles Ltd Nottingham England NG11 6JS am NG11 6JS, England Johnson & Johnson MSD, Consumer Pharmaceut Europe, High Wycombe HP10 9UF, Bucks, England Johnson & Johnson MSD High Wycombe Bucks England HP10 9UF Bucks, England
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
fascicolo: 4, volume: 13, anno: 2001,
pagine: 369 - 374
SICI:
0928-0987(200107)13:4<369:ASSTIT>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PHARMACEUTICAL DOSAGE FORMS; GASTROINTESTINAL TRANSIT; HEALTHY-SUBJECTS; COLONIC TRANSIT; FOOD;
Keywords:
loperamide; simethicone; gastrointestinal transit; gamma scintigraphy; neutron activation; samarium-153;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Wilding, IR Pharmaceut Profiles Ltd, Mere Way,Ruddington Fields,Ruddington, NottinghamNG11 6JS, England Pharmaceut Profiles Ltd Mere Way,Ruddington Fields,Ruddington Nottingham England NG11 6JS
Citazione:
A.L. Conner et al., "A scintigraphic study to investigate the potential for altered gut distribution of loperamide from a loperamide-simethicone formulation in man", EUR J PH SC, 13(4), 2001, pp. 369-374

Abstract

A loperamide simethicone combination formulation has recently been demonstrated to have significant clinical advantages compared to loperamide alone in the relief of diarrhoea and related symptoms. The product visualisation technique of gamma scintigraphy has been used to investigate the interaction of the formulation with the heterogenous environment of the human gut in a group of 12 healthy volunteers. The results suggest that changes: in the intestinal kinetics of loperamide from the combination product, e.g. jejunal coating, could be contributing to the improved efficacy. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 01:17:11