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Titolo:
Color Doppler imaging of untreated and irradiated choroidal melanomas
Autore:
Regan, S; Egan, KM; Hart, L; Gragoudas, ES;
Indirizzi:
Massachusetts Eye & Ear Infirm, Retina Serv, Boston, MA 02114 USA Massachusetts Eye & Ear Infirm Boston MA USA 02114 , Boston, MA 02114 USA
Titolo Testata:
EUROPEAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 150 - 155
SICI:
1120-6721(200104/06)11:2<150:CDIOUA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
UVEAL MELANOMA; TUMOR VASCULARITY; PROGNOSTIC INDICATOR; CILIARY BODY; ANGIOGENESIS; METASTASIS; SKIN; FLOW;
Keywords:
color Doppler ultrasound; ocular melanoma;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Gragoudas, ES Massachusetts Eye & Ear Infirm, Retina Serv, 241 Charles St,Boston, MA 02114 USA Massachusetts Eye & Ear Infirm 241 Charles St Boston MA USA 02114
Citazione:
S. Regan et al., "Color Doppler imaging of untreated and irradiated choroidal melanomas", EUR J OPTHA, 11(2), 2001, pp. 150-155

Abstract

PURPOSE. We examined untreated and irradiated choroidal melanomas with color Doppler imaging (CDI), a noninvasive method providing quantitative measures of blood flow, to determine if the tumor vessel damage associated with irradiation can be detected using this technology. METHODS. CDI was performed on 122 untreated and 76 previously irradiated tumors using a Q2000 color Doppler ultrasound unit. Spectral analysis was performed on all detectable vascular regions within the tumor to obtain estimates of the peak systolic and end diastolic flow velocities and resistive index ((syst-diast)/syst). RESULTS. Vessels were detected in 93% of the untreated tumors and in 63% of the treated tumors (p < 0.001, X-2), and the median number of vascular regions found was higher among untreated tumors (3 vs I, p = 0.001, Wilcoxon Rank Sum). The effect of treatment status on the detection of tumor vesselswas significant (p = 0.039), controlling for age, sex, largest tumor pretreatment diameter, and tumor height at CDI in a logistic regression model. Mean resistive index was lower in the untreated tumors (0.53 vs 0.58, p = 0.0050), controlling for tumor height and other covariates in an analysis of variance. CONCLUSIONS. On examination with CDI, irradiated tumors had fewer detectable vascular regions and greater resistance to flow than untreated tumors, apattern consistent with known radiation effects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/21 alle ore 04:25:55