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Titolo:
Interactions between ocular surface fluid and cornea related to contact lenses
Autore:
Reim, M; Schrage, NF; Becker, J;
Indirizzi:
Aachen Tech Univ, Rhein Westfal TH Aachen, Fac Med, Eye Clin, Aachen, Germany Aachen Tech Univ Aachen Germany hen, Fac Med, Eye Clin, Aachen, Germany
Titolo Testata:
EUROPEAN JOURNAL OF OPHTHALMOLOGY
fascicolo: 2, volume: 11, anno: 2001,
pagine: 105 - 115
SICI:
1120-6721(200104/06)11:2<105:IBOSFA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR; EPITHELIUM; BIOLUMINESCENCE; QUANTIFICATION;
Keywords:
electrolytes; glucose; lactate; hydration; alkali burn; surface rinsing;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Reim, M Aachen Tech Univ Klinikum, Fac Med, Eye Clin, Pauwelsstr 30, D-52057 Aachen, Germany Aachen Tech Univ Klinikum Pauwelsstr 30 Aachen Germany D-52057 ny
Citazione:
M. Reim et al., "Interactions between ocular surface fluid and cornea related to contact lenses", EUR J OPTHA, 11(2), 2001, pp. 105-115

Abstract

PURPOSE. TO improve the quantification of damage to the ocular surface, metabolite levels, electrolyte concentrations, and enzyme activities were assayed in corneal epithelium, stroma and tears. METHODS. In rabbits, rinsing or contact lenses were used to induce microtrauma. For more severe trauma, experimental injuries were induced with 1 N NaOH. Human accidents included epithelial lesions and mild chemical burns. Enzymatic test systems and electron dispersive X-ray analyses (EDXA) were employed. Corneal hydration was assessed by wet and dry weights. Interleukinswere analysed with ELISA. RESULTS. In contrast to normal eyes, in ocular surface trauma the interaction between tear fluid and cornea played an important part. After wearing contact lenses or rinsing, glucose and lactate levels in the cornea and in tears increased, and ATP and glycogen in the cornea decreased. After epithelial lesions, N-acetylglucose aminidase (NAcGA, E.C.3.2.1.50) was released into the tears. Epithelial defects alone and - much more - rinsing the denuded stromal surface produced an increase of lactate and glucose in tears anda dramatic fall in Na, CI, and S levels in the stroma. Rinsing with phosphate induced corneal calcification. IL-l and IL-6 were increased in human corneal buttons from patients with trauma and inflammation. CONCLUSIONS. Biochemical analyses may be useful to quantify trauma to the ocular surface.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 03:58:26