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Titolo:
The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D-1-like, but not D-2-like, dopamine receptors in the rat nucleus accumbens
Autore:
David, HN; Abraini, JH;
Indirizzi:
Univ Caen, Ctr Cyceron, CNRS, UMR 6551, F-14074 Caen, France Univ Caen Caen France F-14074 eron, CNRS, UMR 6551, F-14074 Caen, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 13, anno: 2001,
pagine: 2157 - 2164
SICI:
0953-816X(200106)13:11<2157:TGIMGR>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRAL TEGMENTAL AREA; AMINO-ACID RECEPTOR; STRIATAL DOPAMINE; AGONIST SKF-38393; MESSENGER-RNA; STIMULATION; EXPRESSION; NEURONS; RELEASE; AMPHETAMINE;
Keywords:
dopamine receptors; metabotropic glutamate receptors; nucleus accumbens; striatum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Abraini, JH Univ Caen, Ctr Cyceron, CNRS, UMR 6551, BP 5229,Blvd H Becquerel, F-14074 Caen, France Univ Caen BP 5229,Blvd H Becquerel Caen France F-14074 France
Citazione:
H.N. David e J.H. Abraini, "The group I metabotropic glutamate receptor antagonist S-4-CPG modulates the locomotor response produced by the activation of D-1-like, but not D-2-like, dopamine receptors in the rat nucleus accumbens", EUR J NEURO, 13(11), 2001, pp. 2157-2164

Abstract

Functional interactions between dopamine (DA) and glutamate neurotransmissions in both the dorsal and the ventral striatum have been described for long time. However, there is much controversy as to whether glutamate transmission stimulates or attenuates DA release and locomotor activity. We investigated the functional interactions on locomotor activity between group I metabotropic glutamatergic receptors (mGlu receptors) acid both D-1-like and D-2-like DA receptors in the rat nucleus accumbens. Intra-accumbens administration of the selective group I mGlu receptor antagonist S-4-CPG (0.2 or 2mug per side), which had no effect when injected alone, prevented the increase in locomotor activity produced by the selective D-1-like receptor agonist SKF 38393 (1 mug per side). Co-administration with S-4-CPG of the groupI mGlu receptor agonist DHPG, but not of the group II mGlu receptor agonist APDC or the group III mGlu receptor agonist AP4, reversed the antagonistic effect of S-4-CPG on the SKF 38393-induced increase in locomotor activity. This indicates that the antagonistic effect of S-4-CPG could result from an action at the group I mGlu receptors. In contrast, administration of S-4-CPG showed no effect on the locomotor responses produced by either the selective D-2-like receptor agonist LY 171555 (1 mug per side) or a mixed solution of SKF 38393 + LY 171555 (1 mug per side each). Altogether, these results confirm that glutamate transmission may control locomotor function through mGlu receptors in a DA-dependent manner, and further indicate that group I mGlu receptors would interact with D-1-like receptors, but not D-2-likereceptors, to modulate DA transmission and locomotor activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 20:22:32