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Titolo:
Effect of the selective noradrenergic reuptake inhibitor reboxetine on thefiring activity of noradrenaline and serotonin neurons
Autore:
Szabo, ST; Blier, P;
Indirizzi:
Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL 32610 USA Univ Florida Gainesville FL USA 32610 Psychiat, Gainesville, FL 32610 USA McGill Univ, Neurobiol Psychiat Unit, Montreal, PQ H3A 1A1, Canada McGill Univ Montreal PQ Canada H3A 1A1 Unit, Montreal, PQ H3A 1A1, Canada
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 11, volume: 13, anno: 2001,
pagine: 2077 - 2087
SICI:
0953-816X(200106)13:11<2077:EOTSNR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC DESIPRAMINE TREATMENT; LOCUS-COERULEUS NEURONS; RAT-BRAIN; DORSAL RAPHE; IN-VIVO; ANTIDEPRESSANT TREATMENT; TERM; MODULATION; RECEPTORS; 5-HT;
Keywords:
5-HT1A receptors; alpha(2)-adrenoceptors; antidepressant; dorsal raphe; locus coeruleus; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Blier, P Univ Florida, McKnight Brain Inst, Dept Psychiat, Gainesville, FL32610 USA Univ Florida Gainesville FL USA 32610 Gainesville, FL 32610 USA
Citazione:
S.T. Szabo e P. Blier, "Effect of the selective noradrenergic reuptake inhibitor reboxetine on thefiring activity of noradrenaline and serotonin neurons", EUR J NEURO, 13(11), 2001, pp. 2077-2087

Abstract

Reboxetine is a non-tricyclic antidepressant with selective noradrenergic (NA) reuptake-blocking effects. The effects of acute and sustained administration of reboxetine, on the firing activity of locus coeruleus NA neurons and dorsal raphe 5-HT neurons, were assessed using in vivo extracellular unitary recording in rats anaesthetized with chloral hydrate. Reboxetine (0.1-1.25 mg/kg, i.v.) dose-dependently decreased the firing activity of NA neurons (ED50 = 480 +/- 14 mug/kg). A 2-day treatment with reboxetine at 1.25,2.5, 5, or 10 mg/kg per day (using osmotic minipumps implanted subcutaneously) produced significant decreases of 52%, 58%, 81%, and 83%, respectively, of NA firing activity. When the reboxetine treatment (2.5 mg/kg per day) duration was prolonged to 7 days, a 66% decrease in NA firing activity was observed which further decreased to 80% after 21 days of treatment. In contrast, 5-HT neuron firing rate remained unaltered following short- and long-term reboxetine treatments. The suppressant effect of the alpha (2)-adrenoceptor agonist clonidine on the firing activity of NA neurons was unchanged in long-term reboxetine-treated rats, but its effect on the firing activityof 5-HT neurons was blunted. The enhancement of NA firing activity by the 5-HT1A agonist 8-OH-DPAT was abolished in long-term reboxetine-treated rats, whereas, the inhibitory effect of the 5-HT2 agonist DOI was attenuated byabout three-fold. In conclusion, sustained NA reuptake blockade by reboxetine lead to profound alterations in the function of NA neurons and of 5-HT receptors modulating their firing activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:42:15