Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The absence of SLP65 sand Btk blocks B cell development at the preB cell receptor-positive stage
Autore:
Jumaa, H; Mitterer, M; Reth, M; Nielsen, PJ;
Indirizzi:
Max Planck Inst Immunbiol, D-79108 Freiburg, Germany Max Planck Inst Immunbiol Freiburg Germany D-79108 108 Freiburg, Germany Univ Freiburg, Freiburg, Germany Univ Freiburg Freiburg GermanyUniv Freiburg, Freiburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF IMMUNOLOGY
fascicolo: 7, volume: 31, anno: 2001,
pagine: 2164 - 2169
SICI:
0014-2980(200107)31:7<2164:TAOSSB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
X-LINKED AGAMMAGLOBULINEMIA; ADAPTER PROTEIN SLP-76; TEC FAMILY KINASES; MOUSE BONE-MARROW; PHOSPHOLIPASE C-GAMMA-2; TYROSINE KINASE; CUTTING EDGE; SH2 DOMAIN; MICE; LYMPHOCYTES;
Keywords:
surrogate; lambda 5; VpreB; signaling; deficient;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Jumaa, H Max Planck Inst Immunbiol, Stubeweg 51, D-79108 Freiburg, GermanyMax Planck Inst Immunbiol Stubeweg 51 Freiburg Germany D-79108 y
Citazione:
H. Jumaa et al., "The absence of SLP65 sand Btk blocks B cell development at the preB cell receptor-positive stage", EUR J IMMUN, 31(7), 2001, pp. 2164-2169

Abstract

Mice deficient for the adapter protein SLP65 (BLNK) show a partial block in early B cell development, reduced numbers of mature B cells. in the periphery, an absence of Bl cells and a reduction of IgM and IgG3 serum immunoglobulin levels. A strikingly similar phenotype is observed in Bt[c-deficientmice. To investigate the consequences of mutations in both SLP65 and Btk, we generated SLP65/Btk double-mutant mice by crossing the single-mutant mice. Analysis of the double-mutant mice reveals a much more severe defect in B cell development. B cells in the SLP65/Btk double-mutant mice are arrested at the preB cell stage and, surprisingly, express the preB cell receptor. Normally, preB cell receptor expression in wild-type mice is restricted toa very small fraction of B cells making it difficult to identify these cells in the bone marrow. Together, the data demonstrate the synergistic role of SLP65 and Btk in B cell development and describe a situation where largenumbers of preB cell receptor-positive cells accumulate in the bone marrowand spleen.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/04/20 alle ore 11:26:57