Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy
Autore:
Wada, R; Nishizawa, Y; Yagihashi, N; Takeuchi, M; Ishikawa, Y; Yasumura, K; Nakano, M; Yagihashi, S;
Indirizzi:
Hirosaki Univ, Sch Med, Dept Pathol, Hirosaki, Aomori 0368562, Japan Hirosaki Univ Hirosaki Aomori Japan 0368562 rosaki, Aomori 0368562, Japan Hokuriku Univ, Sch Pharm, Dept Biochem, Kanazawa, Ishikawa 92011, Japan Hokuriku Univ Kanazawa Ishikawa Japan 92011 nazawa, Ishikawa 92011, Japan Otsuka Pharmaceut Co Ltd, Div Res, Tokushima 77101, Japan Otsuka Pharmaceut Co Ltd Tokushima Japan 77101 s, Tokushima 77101, Japan Mitsubishi Gas Chem Co, Dev Anal Sect, Tsukuba, Ibaraki, Japan Mitsubishi Gas Chem Co Tsukuba Ibaraki Japan ct, Tsukuba, Ibaraki, Japan
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 6, volume: 31, anno: 2001,
pagine: 513 - 520
SICI:
0014-2972(200106)31:6<513:EOOAAO>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE FUNCTION; NON-ENZYMATIC GLYCOSYLATION; END-PRODUCTS; ENDOTHELIAL-CELLS; NONENZYMATIC GLYCATION; BLOOD-FLOW; OXIDATIVE STRESS; TISSUE FACTOR; NITRIC-OXIDE; RATS;
Keywords:
advanced glycation end-products; glycation; OPE 9195; motor nerve conduction velocity; neuropathy; oxidative stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Yagihashi, S Hirosaki Univ, Sch Med, Dept Pathol, 5 Zaifu Cho, Hirosaki, Aomori 0368562, Japan Hirosaki Univ 5 Zaifu Cho Hirosaki Aomori Japan 0368562 Japan
Citazione:
R. Wada et al., "Effects of OPB-9195, anti-glycation agent, on experimental diabetic neuropathy", EUR J CL IN, 31(6), 2001, pp. 513-520

Abstract

Background Nonenzymatic glycation of neural proteins and their end-products (advanced glycation end-products, AGE) have been implicated in the pathogenesis of diabetic neuropathy. We need a development of effective ant-glycation agents for future clinical use. Materials and methods We examined the effects of OPB-9195 (OPB), a new inhibitor of glycation, on the peripheral nerve structure and function in diabetic rats. Eight-week-old Wister rats were made diabetic by streptozotocin (40 mg kg(-1), i.v.) and OPE (60 mg kg(-1) day(-1)) was given by gavage for24 weeks. Age- and sex-matched normal Wistar rats were used for comparison. Results During the experimental period, OPE treatment did not affect the reduced body weight, elevated levels of blood glucose and glycated haemoglobin in diabetic rats. At the end of the experiment, delayed tibial motor nerve conduction velocity was significantly improved (by 60%) in treated diabetic rats, with reduction of serum AGE levels. Expression of immunoreactive AGE in the sciatic nerve was reduced in treated diabetic rats compared withthose in untreated rats. Sciatic nerve (Na+,K+)-ATPase activity was also restored in treated diabetic rats. On the cross-sectioned sciatic nerves, positive cells with oxidative stress-related DNA damage, as expressed by 8-hydroxy-2'-deoxyguanosine, were less in the peripheral nerve of treated diabetic rats compared with those of untreated rats. Conclusion The current study suggested that OPE is beneficial for the reduction of serum AGE and the prevention of diabetic neuropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:00:43