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Titolo:
Dual function of rhoD in vesicular movement and cell motility
Autore:
Murphy, C; Saffrich, R; Olivo-Marin, JC; Giner, A; Ansorge, W; Fotsis, T; Zerial, M;
Indirizzi:
Univ Ioannina, Sch Med, Ioannina Biomed Res Inst, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 s Inst, GR-45110 Ioannina, Greece Univ Ioannina, Sch Med, Biol Chem Lab, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 em Lab, GR-45110 Ioannina, Greece Max Planck Inst Mol Cell Biol & Genet, Dresden, Germany Max Planck Inst Mol Cell Biol & Genet Dresden Germany Dresden, Germany EMBL, Heidelberg, Germany EMBL Heidelberg GermanyEMBL, Heidelberg, Germany Inst Pasteur, Lab Anal Images Quantitat, Paris, France Inst Pasteur Paris France eur, Lab Anal Images Quantitat, Paris, France
Titolo Testata:
EUROPEAN JOURNAL OF CELL BIOLOGY
fascicolo: 6, volume: 80, anno: 2001,
pagine: 391 - 398
SICI:
0171-9335(200106)80:6<391:DFORIV>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-MEMBRANE; GROWTH-FACTOR; TUMOR-CELLS; TRANSPORT; MICROTUBULE; RECEPTORS; MIGRATION; INTEGRIN; MOTORS; TRANSFERRIN;
Keywords:
RhoD; vesicular transport; cell motility; endothelial cell; cytoskeleton;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Murphy, C Univ Ioannina, Sch Med, Ioannina Biomed Res Inst, GR-45110 Ioannina, Greece Univ Ioannina Ioannina Greece GR-45110 -45110 Ioannina, Greece
Citazione:
C. Murphy et al., "Dual function of rhoD in vesicular movement and cell motility", EUR J CELL, 80(6), 2001, pp. 391-398

Abstract

The trafficking of intracellular membranes requires the coordination of membrane-cytoskeletal interactions. Rab proteins are key players in the regulation of vesicular transport, while Rho family members control actin-dependent cell functions. We have previously identified a rho protein, rhoD, which is localized to the plasma membrane and early endosomes. When overexpressed, rhoD alters the actin cytoskeleton and plays an important role in endosome organization. We found that a rhoD mutant exerts its effect on early endosome dynamics through an inhibition in organelle motility. In these studies, the effect of rhoD on endosome dynamics was evaluated in the presence of a constitutively active, GTPase-deficient mutant of rab5, rab5Q79L. As rab5Q79L itself stimulates endosome motility, rhoD might counteract this stimulation, without itself exerting any effect in the absence of rab5 activation. We have now addressed this issue by investigating the effect of rhoD inthe absence of co-expressed rab5. We find that rhoDG26V alone alters vesicular dynamics. Vesicular movement, in particular the endocytic/recycling circuit, is altered during processes such as cell motility, Due to the participation of vesicular motility and cytoskeletal rearrangements in cell movement and the involvement of rhoD in both, we have addressed the role of rhoD in this process and have found that rhoDG26V inhibits endothelial cell motility.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:17:01