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Titolo:
Measurement of children's exposure to pesticides: Analysis of urinary metabolite levels in a probability-based sample
Autore:
Adgate, JL; Barr, DB; Clayton, CA; Eberly, LE; Freeman, NCG; Lioy, PJ; Needham, LL; Pellizzari, ED; Quackenboss, JJ; Roy, A; Sexton, K;
Indirizzi:
Univ Minnesota, Sch Publ Hlth, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 l Hlth, Minneapolis, MN 55455 USA Ctr Dis Control & Prevent, Natl Ctr Environm Hlth, Atlanta, GA USA Ctr DisControl & Prevent Atlanta GA USA Environm Hlth, Atlanta, GA USA Res Triangle Inst, Res Triangle Pk, NC 27709 USA Res Triangle Inst Res Triangle Pk NC USA 27709 Triangle Pk, NC 27709 USA Environm & Occupat Hlth Sci Inst, Piscataway, NJ USA Environm & Occupat Hlth Sci Inst Piscataway NJ USA t, Piscataway, NJ USA US EPA, Las Vegas, NV 89193 USA US EPA Las Vegas NV USA 89193US EPA, Las Vegas, NV 89193 USA
Titolo Testata:
ENVIRONMENTAL HEALTH PERSPECTIVES
fascicolo: 6, volume: 109, anno: 2001,
pagine: 583 - 590
SICI:
0091-6765(200106)109:6<583:MOCETP>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
UNITED-STATES; MASS-SPECTROMETRY; CHARACTERIZE; CHLORPYRIFOS; POPULATION; RESIDUES; ADULTS; HEALTH; RISKS;
Keywords:
children's health; exposure assessment; Minnesota Children's Pesticide Exposure Study (MNCPES); National Health and Nutrition Examination Survey (NHANES); National Human Exposure Assessment Survey; (NHEXAS); organophosphate pesticides; urinary biomarkers;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Adgate, JL Univ Minnesota, Sch Publ Hlth, MMC 807,Room 1260,420 Delaware St SE, Minneapolis, MN 55455 USA Univ Minnesota MMC 807,Room 1260,420 Delaware St SE Minneapolis MN USA 55455
Citazione:
J.L. Adgate et al., "Measurement of children's exposure to pesticides: Analysis of urinary metabolite levels in a probability-based sample", ENVIR H PER, 109(6), 2001, pp. 583-590

Abstract

The Minnesota Children's Pesticide Exposure Study is a probability-based sample of 102 children 3-13 years old who were monitored for commonly used pesticides. During the summer of 1997, first-morning-void urine samples (1-3per child) were obtained for 88% of study children and analyzed for metabolites of insecticides and herbicides: carbamates and related compounds (1-NAP), atrazine (Ah?), malathion (MDA), and chlorpyrifos and related compounds (TCPy). TCPy was present in 93% of the samples, whereas 1-NAP, MDA, and AM were detected in 45%, 37%, and 2% of samples, respectively. Measured intrachild means ranged from 1.4 mug/L for MDA to 9.2 mug/L for TCPy, and therewas considerable intrachild variability. For children providing three urine samples, geometric mean TCPy levels were greater than the detection limitin 98% of the samples, and nearly half the children had geometric mean 1-NAP and MDA levels greater than the detection limit. Interchild variability was significantly greater than intrachild variability for 1-NAP (p = 0.0037) and TCPy (p < 0.0001). The four metabolites measured were not correlated within urine samples, and children's metabolite levels did not vary systematically by sex, age, race, household income, or putative household pesticide use. On a log scale, mean TCPy levels were significantly higher in urban than in nonurban children (7.2 vs. 4.7 mug/L; p = 0.036). Weighted population mean concentrations were 3.9 [standard error (SE) = 0.7; 95% confidence interval (CI), 2.5, 5.3] mug/L for 1-NAP, 1.7 (SE = 0.3; 95% CI, 1.1, 2.3) mug/L for MDA, and 9.6 (SE = 0.9; 95% CI, 7.8, 11) mug/L for TCPy. The weighted population results estimate the overall mean and variability of metabolite levels for more than 84,000 children in the census tracts sampled. Levels of 1-NAP were lower than reported adult reference range concentrations,whereas TCPy concentrations were substantially higher. Concentrations of MDA were detected more frequently and found at higher levels in children than in a recent nonprobability-based sample of adults. Overall, Minnesota children's TCPy and MDA levels were higher than in recent population-based studies of adults in the United States, but the relative magnitude of intraindividual variability was similar for adults and children.

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Documento generato il 06/04/20 alle ore 08:37:19