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Titolo:
Clinical efforts to modulate angiogenesis in the adult: gene therapy versus conventional approaches
Autore:
Liau, G; Su, EJ; Dixon, KD;
Indirizzi:
Novartis Co, Gaithersburg, MD 20878 USA Novartis Co Gaithersburg MD USA 20878 rtis Co, Gaithersburg, MD 20878 USA George Washington Univ, Med Ctr, Dept Anat & Cell Biol, Washington, DC 20037 USA George Washington Univ Washington DC USA 20037 , Washington, DC 20037 USA
Titolo Testata:
DRUG DISCOVERY TODAY
fascicolo: 13, volume: 6, anno: 2001,
pagine: 689 - 697
SICI:
1359-6446(20010701)6:13<689:CETMAI>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; CORONARY-ARTERY DISEASE; NORMAL RABBIT ARTERIES; TUMOR-GROWTH; IN-VIVO; FACTOR RECEPTOR; MYOCARDIAL ANGIOGENESIS; RECOMBINANT ADENOVIRUS; MONOCLONAL-ANTIBODIES; TRANSGENE EXPRESSION;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Liau, G Novartis Co, 938 Clopper Rd, Gaithersburg, MD 20878 USA Novartis Co 938 Clopper Rd Gaithersburg MD USA 20878 MD 20878 USA
Citazione:
G. Liau et al., "Clinical efforts to modulate angiogenesis in the adult: gene therapy versus conventional approaches", DRUG DISC T, 6(13), 2001, pp. 689-697

Abstract

A gene therapy approach towards the modulation of neovascularization provides important advantages that could be crucial for the success of therapiesthat target blood vessels. These advantages include sustained local expression and the ability to supply multiple pro- or anti-angiogenic factors. There is potential near-term success in the application of this approach for the treatment of ischemic vascular diseases. Although there is convincing proof of concept in animal models that an anti-angiogenesis gene therapy approach can be used to treat cancer, this is a highly competitive field with small molecules, recombinant proteins and monoclonal antibodies already in clinical trials. The scientific rationale for the use of gene therapy is sound, but realization of its full potential for the treatment of a broad array of diseases will require several challenging technical hurdles to be overcome and safety concerns to be alleviated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:37:06