Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Proapoptotic plasma membrane pore: P2X(7) receptor
Autore:
Morelli, A; Ferrari, D; Bolognesi, G; Rizzuto, R; Di Virgilio, F;
Indirizzi:
Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 ct Gen Pathol, I-44100 Ferrara, Italy Univ Ferrara, Ctr Study Inflammatory Dis, I-44100 Ferrara, Italy Univ Ferrara Ferrara Italy I-44100 lammatory Dis, I-44100 Ferrara, Italy
Titolo Testata:
DRUG DEVELOPMENT RESEARCH
fascicolo: 4, volume: 52, anno: 2001,
pagine: 571 - 578
SICI:
0272-4391(200104)52:4<571:PPMPPR>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PURINERGIC P2Z RECEPTOR; PROTEIN-KINASE-C; EXTRACELLULAR ATP; CELL-DEATH; MACROPHAGE CULTURES; SALIVARY HISTATIN-5; MOUSE LYMPHOCYTES; IL-1-BETA RELEASE; DNA FRAGMENTATION; ENDOTHELIAL-CELLS;
Keywords:
P2X(7) receptor; ATP; plasma membrane; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Di Virgilio, F Univ Ferrara, Dept Expt & Diagnost Med, Sect Gen Pathol, Via Borsari 46, I-44100 Ferrara, Italy Univ Ferrara Via Borsari 46 Ferrara Italy I-44100 a, Italy
Citazione:
A. Morelli et al., "Proapoptotic plasma membrane pore: P2X(7) receptor", DRUG DEV R, 52(4), 2001, pp. 571-578

Abstract

ATP is not only the universal currency of energy metabolism but also a ubiquitous extracellular messenger. Among its many effects the ability to trigger cell death has attracted considerable interest. The plasma membrane receptor responsible for this effect has been cloned and shown to belong to the P2X family (P2X(7)). The P2X(7) receptor is a plasma membrane ion channelthat, under certain conditions, can grow to form a nonselective pore. Prolonged opening of this receptor is a potent apoptotic stimulus for several cell types. The main mechanism responsible for this deadly effect seems to reside in the drastic upset of the intracellular concentration of Ca2+ as well as K+. The loss of intracellular K+ has a permissive effect on the progression of apoptosis by causing the activation of key proapoptotic enzymes such as caspase 3 and NUC18. The P2X(7) receptor could be an interesting model for the study of apoptotic pathways triggered by plasma membrane channels. Drug Dev. Res. 52:571-578, 2001. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 14:12:07