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Titolo:
Sex differences in opioid antinociception: kappa and 'mixed action' agonists
Autore:
Craft, RM; Bernal, SA;
Indirizzi:
Washington State Univ, Dept Psychol, Pullman, WA 99164 USA Washington State Univ Pullman WA USA 99164 Psychol, Pullman, WA 99164 USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 3, volume: 63, anno: 2001,
pagine: 215 - 228
SICI:
0376-8716(20010801)63:3<215:SDIOAK>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR-MEDIATED ANTINOCICEPTION; STRESS-INDUCED ANALGESIA; APPARENT PA(2) ANALYSIS; FEMALE RATS; RHESUS-MONKEYS; MORPHINE ANTINOCICEPTION; THERMAL ANTINOCICEPTION; PERIAQUEDUCTAL GRAY; MU-RECEPTOR; BINDING;
Keywords:
kappa-opioids; analgesia; locomotor activity; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Craft, RM Washington State Univ, Dept Psychol, POB 644820, Pullman, WA 99164 USA Washington State Univ POB 644820 Pullman WA USA 99164 99164 USA
Citazione:
R.M. Craft e S.A. Bernal, "Sex differences in opioid antinociception: kappa and 'mixed action' agonists", DRUG AL DEP, 63(3), 2001, pp. 215-228

Abstract

A number of investigators have shown that male animals are more sensitive than females to the antinociceptive effects of mu -opioid agonists. The present study was conducted to examine sex differences in opioid antinociception in the rat using agonists known to differ in selectivity for and efficacy at kappa- versus mu -receptors. Dose- and time-effect curves were obtained for s.c. U69593, U50488, ethylketazocine. (-)-bremazocine, (-)-pentazocine, butorphanol and nalbuphine on the 50 or 54 degreesC hotplate and warm water tail withdrawal assays; spontaneous locomotor activity was measured 32-52 min post-injection in the same rats. On the hotplate assay, only butorphanol (54 degreesC) and nalbuphine (50 degreesC) were significantly more potent in males than females. On the tail withdrawal assay, all agonists were significantly more potent or efficacious in males than females at one or both temperatures. In contrast, no agonist was consistently more potent in one sex or the other in decreasing locomotor activity. Estrous stage in female rats only slightly influenced opioid effects, accounting for an average of 2.6% of the variance in females' antinociceptive and locomotor responses to drug (50 degreesC experiment). These results suggest that (1) sex differences in antinociceptive effects of opioids are not mu -receptor-dependent.as they may occur with opioids known to have significant kappa -receptor-mediated activity; (2) the mechanisms underlying sex differences in kappa -opioid antinociception may be primarily spinal rather than supraspinal; (3) sex differences in antinociceptive effects of opioid agonists are not secondary to sex differences in their sedative effects. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 13:58:45