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Titolo:
Aldosteronoma in a dog with polyuria as the leading symptom
Autore:
Rijnberk, A; Kooistra, HS; van Vonderen, IK; Mol, JA; Voorhout, G; van Sluijs, FJ; Ijzer, J; van den Ingh, TSGAM; Boer, P; Boer, WH;
Indirizzi:
Univ Utrecht, Fac Med Vet, Dept Clin Sci Companion Anim, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands Univ Utrecht, Fac Med Vet, Div Diagnost Imaging, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands Univ Utrecht, Fac Med Vet, Dept Pathol, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC 3508 TC Utrecht, Netherlands Univ Utrecht, Med Ctr, Dept Nephrol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands tr, Dept Nephrol, Utrecht, Netherlands
Titolo Testata:
DOMESTIC ANIMAL ENDOCRINOLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 227 - 240
SICI:
0739-7240(200104)20:3<227:AIADWP>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
MINERALOCORTICOID ACTION; VASOPRESSIN RELEASE; SPIRONOLACTONE; HYPERADRENOCORTICISM; RESISTANCE; DIAGNOSIS; EXCESS; PLASMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Rijnberk, A Univ Utrecht, Fac Med Vet, Dept Clin Sci Companion Anim, NL-3508 TC Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 TC cht, Netherlands
Citazione:
A. Rijnberk et al., "Aldosteronoma in a dog with polyuria as the leading symptom", DOM ANIM EN, 20(3), 2001, pp. 227-240

Abstract

In a 10-year-old castrated male shorthaired German pointer polyuria was associated with slight hypokalemia, hypophosphatemia and alkalosis, as well as elevated plasma concentrations of a glucocorticoid-inducible iso-enzyme of alkaline phosphatase. Repeated measurements of urinary corticoids and normal suppressibility of the hypothalamus-pituitary-adrenocorticial axis excluded glucocorticoid excess,Urine osmolality (Uosm) did not increase during administration of the vasopressin analogue desmopressin. At the time water deprivation had caused Uosm to rise from 300 to 788 mOsm/kg, there was also plasma hypertonicity. During hypertonic saline infusion the osmotic threshold for vasopressin release was increased. The combination of elevated plasma aldosterone concentrations and unmeasurably low plasma renin activity pointed to primary hyperaldosteronism. As initially computed tomography (CT) did not reveal an adrenocortical lesion, the dog was treated with the aldosterone antagonist spironolactone. This caused Uosm to rise in a dose-dependent manner. However, well-concentrated urine was only achieved with doses that gave rise to adverse effects. Once repeated CT, using 2-mm-thick slices, had revealed a small nodule in the cranial pole of the left adrenal, unilateral adrenalectomy was performed which resolved the polyuria completely. Also the plasma concentrations ofkalium, aldosterone and renin activity returned to within their respectivereference ranges. The adrenocortical nodule had the histological characteristics of an aldosteronoma, with the non-affected zona glomerulosa being atrophic. In this dog with primary hyperaldosteronism the polyuria was characterizedby vasopressin resistance and increased osmotic threshold of vasopressin release, similar to the polyuria of glucocorticoid excess. The possibility is discussed that the polyuria of glucocorticoid excess is actually a mineralocorticoid effect. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/12/18 alle ore 00:35:41