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Titolo:
Hormone control of prostaglandin F-2 alpha production and oxytocin receptor concentrations in bovine endometrium in explant culture
Autore:
Mann, GE;
Indirizzi:
Univ Nottingham, Sch Biosci, Div Anim Physiol, Loughborough LE12 5RD, Leics, England Univ Nottingham Loughborough Leics England LE12 5RD 2 5RD, Leics, England
Titolo Testata:
DOMESTIC ANIMAL ENDOCRINOLOGY
fascicolo: 3, volume: 20, anno: 2001,
pagine: 217 - 226
SICI:
0739-7240(200104)20:3<217:HCOPFA>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
OVARIECTOMIZED EWES; EXOGENOUS PROGESTERONE; OVINE ENDOMETRIUM; UTERINE SECRETION; OVARIAN HORMONES; ESTRADIOL; RELEASE; UTERUS; LUTEOLYSIS; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Mann, GE Univ Nottingham, Sch Biosci, Div Anim Physiol, Loughborough LE12 5RD, Leics, England Univ Nottingham Loughborough Leics England LE12 5RD ics, England
Citazione:
G.E. Mann, "Hormone control of prostaglandin F-2 alpha production and oxytocin receptor concentrations in bovine endometrium in explant culture", DOM ANIM EN, 20(3), 2001, pp. 217-226

Abstract

The effect of progesterone and estradiol on basal and oxytocin-stimulated prostaglandin F-2 alpha production and on oxytocin receptor concentrations in endometrium from long term ovariectomized cows was investigated using anexplant culture system. Uteri were obtained from cows at slaughter and endometrial explants were cultured in triplicate for up to 96 h in either control media, or media containing progesterone or estradiol. Basal prostaglandin F-2 alpha production was unaffected by progesterone treatment but was stimulated by estradiol treatment in a dose dependent manner. Oxytocin receptor concentrations remained unchanged in control culture and were unaffectedby treatment with estradiol while treatment with progesterone caused a dose-dependent inhibition. Responsiveness to oxytocin, in terms of increased prostaglandin F-2 alpha production, developed "spontaneously" over the first24 h of culture and was unaffected by treatment with progesterone or estradiol. In summary the results reveal a dose-dependent inhibition of oxytocinreceptor concentration by progesterone and a dose-dependent stimulation ofbasal PGF(2 alpha) release by estradiol. The reason for the "spontaneous" development of responsiveness to oxytocin remains unknown but may result from the removal of tissue from the influence of an, as yet unidentified, inhibitory factor. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 23:09:18