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Titolo:
Abnormal cardiovascular reflex tests are predictors of mortality in Type 2diabetes mellitus
Autore:
Chen, HS; Hwu, CM; Kuo, BI; Chaing, SC; Kwok, CF; Lee, SH; Lee, YS; Weih, MJ; Hsiao, LC; Lin, SH; Ho, LT;
Indirizzi:
Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan Vet Gen Hosp Taipei Taiwan en Hosp, Dept Med Res & Educ, Taipei, Taiwan Vet Gen Hosp, Dept Med, Sect Gen Med, Taipei, Taiwan Vet Gen Hosp TaipeiTaiwan Hosp, Dept Med, Sect Gen Med, Taipei, Taiwan Vet Gen Hosp, Sect Endocrinol & Metab, Taipei, Taiwan Vet Gen Hosp Taipei Taiwan osp, Sect Endocrinol & Metab, Taipei, Taiwan Natl Yang Ming Univ, Sch Med, Fac Med, Taipei 112, Taiwan Natl Yang Ming Univ Taipei Taiwan 112 h Med, Fac Med, Taipei 112, Taiwan
Titolo Testata:
DIABETIC MEDICINE
fascicolo: 4, volume: 18, anno: 2001,
pagine: 268 - 273
SICI:
0742-3071(200104)18:4<268:ACRTAP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
AUTONOMIC NEUROPATHY; VASCULAR-DISEASE; CARDIORESPIRATORY REFLEXES; LONDON COHORT; FOLLOW-UP; PREVALENCE; POPULATION; HYPERTENSION; HYPOTENSION; EXPERIENCE;
Keywords:
autonomic neuropathy; cardiovascular reflex tests; mortality; postural hypotension; Type 2 diabetes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Ho, LT Vet Gen Hosp, Dept Med Res & Educ, Taipei, Taiwan Vet Gen Hosp Taipei Taiwan , Dept Med Res & Educ, Taipei, Taiwan
Citazione:
H.S. Chen et al., "Abnormal cardiovascular reflex tests are predictors of mortality in Type 2diabetes mellitus", DIABET MED, 18(4), 2001, pp. 268-273

Abstract

Aims To determine whether diabetic autonomic neuropathy is an important factor contributing to mortality in Type 2 diabetes mellitus. Methods Between 1989 and 1993, 431 men and 181 women with Type 2 diabetes were given diabetic autonomic neuropathy cardiovascular reflex (CVR) tests. These subjects were followed for the subsequent 5-9 years to assess mortality rates. Results The prevalence rate of abnormal CVR tests was 46.1% in patients with the history of diabetes less than 5 years and up to 69.4% when the history of diabetes exceeded 20 years. During the follow-up period from 1 January 1989 to 31 December 1997 (mean 7.7 years), a total of 135 participants died. The 8-year survival rate for patients with abnormal CVR tests was 63.6%in males and 76.4% in females, compared with 80.9 and 93.3% for patients with normal CVR rests. The results were grouped as: group 1, normal CVR tests without postural hypotension (PHT); group 2, normal CVR tests with PHT; group 3, abnormal CVR tests without PHT; and group 4, abnormal CVR tests with PHT. The 8-year survival rate was 85.4% in group 1, 80.9% in group 2, 74.5% in group 3 and 61.1% in group 4. Conclusion Type 2 diabetic patients with abnormal CVR tests may have increased mortality, and those combined with postural hypotension have higher mortality than those without. Abnormal CVR tests may be important predictors of mortality in Type 2 diabetes mellitus.

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Documento generato il 24/11/20 alle ore 13:56:16