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Titolo:
Erectile dysfunction and lower androgenicity in type 1 diabetic patients
Autore:
Alexopoulou, O; Jamart, J; Maiter, D; Hermans, MP; De Hertogh, R; De Nayer, P; Buysschaert, M;
Indirizzi:
Univ Catholique Louvain, Serv Endocrinol & Nutr, Clin Univ St Luc, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium Univ Catholique Louvain, Clin Univ Mont Godinne, Ctr Biostat & Documentat Med, B-5530 Yvoir, Belgium Univ Catholique Louvain Yvoir Belgium B-5530 Med, B-5530 Yvoir, Belgium Univ Catholique Louvain, Clin Univ St Luc, Serv Med Nucl, B-1200 Brussels,Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels,Belgium
Titolo Testata:
DIABETES & METABOLISM
fascicolo: 3, volume: 27, anno: 2001,
pagine: 329 - 336
SICI:
1262-3636(200106)27:3<329:EDALAI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
HORMONE-BINDING GLOBULIN; DEHYDROEPIANDROSTERONE DHEA; IMPOTENCE; MEN; MELLITUS; SULFATE; SERUM; MANAGEMENT;
Keywords:
diabetes type 1; erectile dysfunction; diabetic complications; adrenal androgens; gonadal androgens;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Buysschaert, M Univ Catholique Louvain, Serv Endocrinol & Nutr, Clin Univ St Luc, Hippocrate 54,UCL 54, B-1200 Brussels, Belgium Univ Catholique Louvain Hippocrate 54,UCL 54 Brussels Belgium B-1200
Citazione:
O. Alexopoulou et al., "Erectile dysfunction and lower androgenicity in type 1 diabetic patients", DIABETE MET, 27(3), 2001, pp. 329-336

Abstract

Objective: To analyse the clinical characteristics and relevant hormonal profile in type 1 diabetic patients with and without ED. Material and methods: Fifty one type 1 diabetic patients were studied. ED was assessed by direct interview. Chronic diabetic complications, smoking and alcohol status as well as current use of medications were recorded. Hormonal profile consisted of plasma LH, FSH, prolactin, androstenedione (Delta(4)), dehydroepiandrosterone (DHEA), DHEA-sulfate (DHEAS), free testosterone (FT), estradiol (E-2), sex hormone binding globulin (SHBG), dihydrotestosterone (DHT), cortisol, TSH and free thyroxine (FT4). Results: EO was present in 24 patients (47%) (group 1), who were older(P <0.001), had a longer diabetes duration (P < 0.001) and a higher systolic blood pressure (P = 0.017) when compared to the subjects who did nor complain (group 2). ED was positively correlated to ail diabetes-related complications (P < 0.02). Antidepressive drug(s) were more frequent in group 1 (P = 0.007), as well as prokinetics (P = 0.043) and ACE-inhibitors (P = 0.010). HbA(1)c was comparable. Patients with ED had lower levels of Delta (4) (P =0.003), DHEA(P < 0.001), DHEA-S (P = 0.002), FT(P = 0.08)while SHBG (P = 0.010) and LH (P = 0.022) were higher compared to group 2. Multiple logisticregression analysis showed an independent association of ED with Delta (4)(P = 0.016), DHEA-S (P = 0.037), SHBG (P = 0.001) and insulin dose (P = 0.025). There was no significant difference for all other measured hormones. Conclusion: ED is impressively prevalent in type 1 diabetes and is associated with age, diabetes duration, chronic complications and decreased androgens.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:20:48