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Titolo:
N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons
Autore:
Kohtz, JD; Lee, HY; Gaiano, N; Segal, J; Ng, E; Larson, T; Baker, DP; Garber, EA; Williams, KP; Fishell, G;
Indirizzi:
Northwestern Univ, Sch Med, Childrens Mem Inst Res & Educ, Program Neurobiol, Chicago, IL 60614 USA Northwestern Univ Chicago IL USA 60614 m Neurobiol, Chicago, IL 60614 USA Northwestern Univ, Sch Med, Childrens Mem Inst Res & Educ, Dept Pediat, Chicago, IL 60614 USA Northwestern Univ Chicago IL USA 60614 Dept Pediat, Chicago, IL 60614 USA NYU, Skirball Inst, Sch Med, Dept Cell Biol, New York, NY 10016 USA NYU New York NY USA 10016 Sch Med, Dept Cell Biol, New York, NY 10016 USA 14 Cambridge Ctr, Cambridge, MA 02142 USA 14 Cambridge Ctr Cambridge MA USA 02142 idge Ctr, Cambridge, MA 02142 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 12, volume: 128, anno: 2001,
pagine: 2351 - 2363
SICI:
0950-1991(200106)128:12<2351:NFOSHE>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
PALMITOYL-PROTEIN THIOESTERASE; DEVELOPING NERVOUS-SYSTEM; ANTERIOR NEURAL PLATE; FLOOR PLATE; MAMMALIAN TELENCEPHALON; STRIATAL INTERNEURONS; MOUSE FOREBRAIN; HOMEOBOX GENE; CHICK-EMBRYO; CELL FATE;
Keywords:
sonic hedgehog; forebrain; telencephalon; fatty-acylation; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Kohtz, JD Northwestern Univ, Sch Med, Childrens Mem Inst Res & Educ, Program Neurobiol, 2430 N Halsted,Box 209, Chicago, IL 60614 USA Northwestern Univ 2430 N Halsted,Box 209 Chicago IL USA 60614 SA
Citazione:
J.D. Kohtz et al., "N-terminal fatty-acylation of sonic hedgehog enhances the induction of rodent ventral forebrain neurons", DEVELOPMENT, 128(12), 2001, pp. 2351-2363

Abstract

The adult basal ganglia arise from the medial and lateral ganglionic eminences, morphologically distinct structures found in the embryonic telencephalon. We have previously shown that temporal changes in sonic hedgehog (Shh)responsiveness determine the sequential induction of embryonic neurons that populate the medial and lateral ganglionic eminences. In this report, we show that Shh-mediated differentiation of neurons that populate the lateralganglionic eminence express different combinations of the homeobox-containing transcription factors Dir, Mash1 and Islet 1/2, Furthermore, we show that N-terminal fatty-acylation of Shh significantly enhances its ability to induce the differentiation of rat Ell telencephalic neurons expressing Dir,Islet 1/2 or Mash1. Recent evidence indicates that in utero injection of the E9.5 mouse forebrain with retroviruses encoding wild-type Shh induces the ectopic expression of D1x2 and severe deformities in the brain, In this report, we show that Shh containing a mutation at the site of acylation prevents either of these phenotypes, These results suggest that N-terminal fatty-acylation of Shh may play an important role in Shh-dependent signaling during rodent ventral forebrain formation.

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Documento generato il 20/01/20 alle ore 08:21:57