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Titolo:
Hoxd10 induction and regionalization in the developing lumbosacral spinal cord
Autore:
Lance-Jones, C; Omelchenko, N; Bailis, A; Lynch, S; Sharma, K;
Indirizzi:
Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 urobiol, Pittsburgh, PA 15261 USA Univ Chicago, Dept Neurobiol Pharmacol & Physiol, Chicago, IL 60637 USA Univ Chicago Chicago IL USA 60637 rmacol & Physiol, Chicago, IL 60637 USA
Titolo Testata:
DEVELOPMENT
fascicolo: 12, volume: 128, anno: 2001,
pagine: 2255 - 2268
SICI:
0950-1991(200106)128:12<2255:HIARIT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC MOTOR-NEURONS; CENTRAL-NERVOUS-SYSTEM; MUSCULATURE FOLLOWING TRANSPLANTATION; ANTERIOR-POSTERIOR AXIS; THORACIC NEURAL-TUBE; LIM HOMEOBOX GENES; CHICK HIND LIMB; PARAXIAL MESODERM; NEURITE OUTGROWTH; ROSTROCAUDAL PATTERN;
Keywords:
chick embryo; spinal cord; axial patterning; Hox genes; motoneuron; paraxial mesoderm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
83
Recensione:
Indirizzi per estratti:
Indirizzo: Lance-Jones, C Univ Pittsburgh, Sch Med, Dept Neurobiol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 urgh, PA 15261 USA
Citazione:
C. Lance-Jones et al., "Hoxd10 induction and regionalization in the developing lumbosacral spinal cord", DEVELOPMENT, 128(12), 2001, pp. 2255-2268

Abstract

We have used Hoxd10 expression as a primary marker of the lumbosacral region to examine the early programming of regional characteristics within the posterior spinal cord of the chick embryo, Hoxd10 is uniquely expressed at a high level in the lumbosacral cord, from the earliest stages of motor column formation through stages of motoneuron axon outgrowth. To define the time period when this gene pattern is determined, we assessed Hoxd10 expression after transposition of lumbosacral and thoracic segments at early neuraltube stages. We present evidence that there is an early prepattern for Hoxd10 expression in the lumbosacral neural tube; a prepattern that is established at or before stages of neural tube closure, Cells within more posterior lumbosacral segments have a greater ability to develop high level Hoxd10 expression than the most anterior lumbosacral segments or thoracic segments. During subsequent neural tube stages, this prepattern is amplified and stabilized by environmental signals such that all lumbosacral segments acquire the ability to develop high levels of Hoxd10, independent of their axial environment. Results from experiments in which posterior neural segments and/or paraxial mesoderm segments were placed at different axial levels suggest that signals setting Hoxd10 expression form a decreasing posterior-to-anterior gradient. Our experiments do not, however, implicate adjacent paraxial mesoderm as the only source of graded signals. We suggest, instead, thatsignals from more posterior embryonic regions influence Hoxd10 expression after the early establishment of a regional prepattern, Concurrent analysesof patterns of LIM proteins and motor column organization after experimental surgeries suggest that the programming of these characteristics follows similar rules.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 12:46:59