Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Serotonin receptor and transporter ligands - Current status
Autore:
Oh, SJ; Ha, HJ; Chi, DY; Lee, HK;
Indirizzi:
Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, Kyunggi Do, South Korea Hankuk Univ Foreign Studies Yongin Kyunggi Do South Korea 449791 th Korea Inha Univ, Dept Chem, Inchon 402751, South Korea Inha Univ Inchon South Korea 402751 ept Chem, Inchon 402751, South Korea Univ Ulsan, Coll Med, Asan Med Ctr, Dept Nucl Med, Seoul 138736, South Korea Univ Ulsan Seoul South Korea 138736 Nucl Med, Seoul 138736, South Korea
Titolo Testata:
CURRENT MEDICINAL CHEMISTRY
fascicolo: 9, volume: 8, anno: 2001,
pagine: 999 - 1034
SICI:
0929-8673(200107)8:9<999:SRATL->2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POTENTIAL ANTIMIGRAINE AGENTS; DIFFERENT INTRINSIC EFFICACY; TERMINAL AMIDE FRAGMENT; IN-VIVO EVALUATION; 5-HT1A RECEPTOR; HIGH-AFFINITY; H5-HT1D RECEPTOR; PARTIAL AGONISTS; BIOLOGICAL EVALUATION; GUINEA-PIG;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
180
Recensione:
Indirizzi per estratti:
Indirizzo: Ha, HJ Hankuk Univ Foreign Studies, Dept Chem, Yongin 449791, Kyunggi Do, South Korea Hankuk Univ Foreign Studies Yongin Kyunggi Do South Korea 449791 a
Citazione:
S.J. Oh et al., "Serotonin receptor and transporter ligands - Current status", CURR MED CH, 8(9), 2001, pp. 999-1034

Abstract

The serotonin (5-HT) receptor system has 14 different subtypes classified by pharmacology and function. Many ligands are widely used for therapeutic and diagnostic purposes in some severe human diseases. Most of the ligands that are specific for each 5-HT receptor have distinctive chemical structures with regard to pharmacophore elements including 4-arylpiperazine, benzimidazole, benzamide, chroman, aminopyridazine, tetralin, and polycycles. However, their affinity and selectivity for 5-HT, dopamine and alpha1 receptors depend on their substituents and linker spacers. 5-HT transporter inhibitors have also been developed as potential antidepressants. In contrast to classical tricyclic compounds, newly developed secondary amine derivatives such as paroxetine and tetralin show high binding affinity and selectivity. Radioisotope-labeled ligands have also been developed, including [carbonyl-C-11]WAY 100635 for 5-HT1A receptor, [C-11 or F-18]ketanserine derivatives for 5-HT2 receptor, [I-125]DAIZAC for 5-HT3 receptor, and [I-123]IDAM for 5-HT transporter, and these are accumulated in brain regions that are rich in the respective receptors. This review summarizes the recent development of 5-HT receptor- and transporter-specific ligands and their pharmacologicalproperties on the basis of their chemical structures.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 18:27:13