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Titolo:
Treatment of refractory recurrent malignant glioma with adoptive cellular immunotherapy: a case report
Autore:
Huang, YW; Hayes, RL; Wertheim, S; Arbit, E; Scheff, R;
Indirizzi:
Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood Related Dis, Immunotherapy Program, Staten Isl, NY 10305 USA Staten Isl Univ Hosp Staten Isl NY USA 10305 am, Staten Isl, NY 10305 USA Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood Related Dis, DeptMed, Staten Isl, NY 10305 USA Staten Isl Univ Hosp Staten Isl NY USA 10305ed, Staten Isl, NY 10305 USA Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood Related Dis, DeptLab Med, Staten Isl, NY 10305 USA Staten Isl Univ Hosp Staten Isl NY USA 10305 ed, Staten Isl, NY 10305 USA Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood Related Dis, DeptRadiol, Staten Isl, NY 10305 USA Staten Isl Univ Hosp Staten Isl NY USA 10305 ol, Staten Isl, NY 10305 USA Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood Related Dis, DeptNeurosurg, Staten Isl, NY 10305 USA Staten Isl Univ Hosp Staten Isl NY USA10305 rg, Staten Isl, NY 10305 USA
Titolo Testata:
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
fascicolo: 1-2, volume: 39, anno: 2001,
pagine: 17 - 23
SICI:
1040-8428(200107/08)39:1-2<17:TORRMG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATED KILLER-CELLS; HIGH-GRADE ASTROCYTOMAS; PRIMARY BRAIN-TUMORS; LAK CELLS; RECOMBINANT INTERLEUKIN-2; GLIOBLASTOMA-MULTIFORME; AUTOLOGOUS LYMPHOCYTES; THERAPY; MEDULLOBLASTOMA; EOSINOPHILS;
Keywords:
glioblastoma; IL-2; immunotherapy; interleukin-2; LAK; lymphokine-activated killer cells; malignant glioma; survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Hayes, RL Staten Isl Univ Hosp, Sanford R Nalitt Inst Canc & Blood RelatedDis, Immunotherapy Program, 256 Mason Ave, Staten Isl, NY 10305 USA StatenIsl Univ Hosp 256 Mason Ave Staten Isl NY USA 10305 5 USA
Citazione:
Y.W. Huang et al., "Treatment of refractory recurrent malignant glioma with adoptive cellular immunotherapy: a case report", CR R ONC H, 39(1-2), 2001, pp. 17-23

Abstract

We report the successful treatment of a patient with recurrent malignant glioma with adoptive cellular immunotherapy. The patient is a young adult with recurrent progressive disease refractory to aggressive multi-modality therapy including repetitive surgical resection, radiation, radiosurgery and chemotherapy. He received multiple courses of local administration of autologous lymphokine-activated killer (LAK) cells in combination with a low dose of interleukin-2 (IL-2) through an Ommaya reservoir-catheter system. The side-effects of this treatment were limited and manageable. The patient achieved a complete remission, as demonstrated by MRI and confirmed by glucose-positron emission tomography (PET) imaging 11 months after initiation of immune therapy. Twenty-six months later, the patient is still in remission with improving performance status. Adoptive cellular immunotherapy utilizingautologous LAK cells with low dose IL-2 appears to be a safe and effectivetherapy for a subset of patients with primary, recurrent or progressive malignant glioma following conventional therapy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 08:29:36