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Titolo:
Restoration of the jejunal mucosa in rats refed after prolonged fasting
Autore:
Dunel-Erb, S; Chevalier, C; Laurent, P; Bach, A; Decrock, F; Le Maho, Y;
Indirizzi:
CNRS, Ctr Ecol Physiol Energet, F-67087 Strasbourg 2, France CNRS Strasbourg France 2 l Physiol Energet, F-67087 Strasbourg 2, France
Titolo Testata:
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR AND INTEGRATIVE PHYSIOLOGY
fascicolo: 4, volume: 129, anno: 2001,
pagine: 933 - 947
SICI:
1095-6433(200107)129:4<933:ROTJMI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMALL-INTESTINE; EPITHELIAL-CELLS; BRUSH-BORDER; STARVATION; MIGRATION; PROTEIN; METABOLISM; APOPTOSIS; CRYPTS; MODEL;
Keywords:
fasting; refeeding; rat; intestine; jejunum; morphometrical study; morphological study; crypt size; villous size; environmental scanning electron microscopy (ESEM);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Dunel-Erb, S CNRS, Ctr Ecol Physiol Energet, 23 Rue Becquerel, F-67087 Strasbourg 2, France CNRS 23 Rue Becquerel Strasbourg France 2 rasbourg 2, France
Citazione:
S. Dunel-Erb et al., "Restoration of the jejunal mucosa in rats refed after prolonged fasting", COMP BIOC A, 129(4), 2001, pp. 933-947

Abstract

To investigate the importance of body fuel depletion on gut rehabilitationafter food deprivation, we compared the kinetics of jejunal mucosa alteration and restoration in rats that were refed after reaching different stagesin body fuel depletion. Rats (P2) were refed while still in the so-called phase II, where body protein utilization is minimized, whereas rats (P3) were refed when they had reached the stage of increasing protein utilization (phase III). There was a significant decrease in total mass of intestine (P2, -30%; P3, -40%) and jejunal mucosa (P2, - 52%; P3, - 60%), as well in the size of the crypts (P2, - 15%; P3, - 36%) and villi (P2, - 37%; P3, - 55%). Structural changes of the mucosa included disappearance of some villi and a reduction in the size and number of crypts. Despite the larger morphological alterations in P3, the restoration of mucosa was as fast: and complete after only 3 days of refeeding for both P2 and P3 rats. The respective roles of the mitosis pressure and of the lamina propria dynamics were studied. The rapid reversibility of the gut mucosal alterations due to fasting might constitute an integrative process. (C) 2001 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 21:23:37