Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Changes in electrovestibular brainstem responses after aminoglycoside intoxication in guinea pigs
Autore:
Sugasawa, K; de Sauvage, RC; da Costa, DML; Erre, JP; Sugasawa, M; Aran, JM;
Indirizzi:
Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, Tokyo 1138655, Japan Univ Tokyo Tokyo Japan 1138655 laryngol, Bunkyo Ku, Tokyo 1138655, Japan Hop Pellegrin, INSRM EMI 99 27, Lab Audiol Expt & Clin, F-33076 Bordeaux, France Hop Pellegrin Bordeaux France F-33076 t & Clin, F-33076 Bordeaux, France
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 7, volume: 112, anno: 2001,
pagine: 1357 - 1363
SICI:
1388-2457(200107)112:7<1357:CIEBRA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
STIMULATION; ACCELERATION; GENTAMICIN;
Keywords:
electrical stimulation; rotational stimulation; vestibular evoked responses; vestibular function; aminoglycoside ototoxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Sugasawa, K Univ Tokyo, Fac Med, Dept Otolaryngol, Bunkyo Ku, 1-6-7 Hongo,Tokyo 1138655, Japan Univ Tokyo 1-6-7 Hongo Tokyo Japan 1138655 kyo 1138655, Japan
Citazione:
K. Sugasawa et al., "Changes in electrovestibular brainstem responses after aminoglycoside intoxication in guinea pigs", CLIN NEU, 112(7), 2001, pp. 1357-1363

Abstract

Objective: To verify the usefulness of short-latency vestibular responses evoked by a combination of round window electrical stimulation and sinusoidal rotation (electrovestibular brainstem responses; EVBRs) as a new monitoring tool of the vestibular function in animal experiments. Methods: EVBRs were obtained before, during, and after treatment with aminoglycosides, along with compound action potential (CAP) audiograms. The changes in EVBRs were compared with morphological changes observed by scanningelectron microscopy. Results: EVER amplitudes did not change in the group of guinea pigs treated with amikacin, but markedly decreased in the streptomycin and gentamicin-treated groups. CAP audiograms indicated a significant threshold elevationin the amikacin group, a moderate elevation in the gentamicin group, and no change in the streptomycin group. Under scanning electron microscopy, theloss of the sensory hair cells observed in the cristae ampullares was slight to moderate in the amikacin group, moderate to severe in the streptomycin group, and severe in the gentamicin group. Conclusion: EVBRs reflect overall pathological changes undergone by vestibular hair cells, and support the vestibular specificity of EVBRs. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 10:27:01