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Titolo:
Changes of the brain electrical fields during the continuous performance test in attention-deficit hyperactivity disorder-boys depending on methylphenidate medication
Autore:
Zillessen, KE; Scheuerpflug, P; Fallgatter, AJ; Strik, WK; Warnke, A;
Indirizzi:
Univ Hosp, Dept Child & Adolescent Psychiat, EEG EP Mapping Lab, D-97080 Wurzburg, Germany Univ Hosp Wurzburg Germany D-97080 apping Lab, D-97080 Wurzburg, Germany Univ Hosp, Dept Psychiat, EEG EP Mapping Lab, Wurzburg, Germany Univ HospWurzburg Germany chiat, EEG EP Mapping Lab, Wurzburg, Germany Univ Hosp Clin Psychiat, Bern, Switzerland Univ Hosp Clin Psychiat Bern Switzerland in Psychiat, Bern, Switzerland
Titolo Testata:
CLINICAL NEUROPHYSIOLOGY
fascicolo: 7, volume: 112, anno: 2001,
pagine: 1166 - 1173
SICI:
1388-2457(200107)112:7<1166:COTBEF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; POSITRON EMISSION TOMOGRAPHY; EEG MAP SERIES; CHILDREN; CHILDHOOD; SEGMENTATION; IMPULSIVITY; METABOLISM; MODEL; ERP;
Keywords:
continuous performance test; electrophysiology; evoked potentials; brain mapping; spatial analysis; children; attention-deficit hyperactivity disorder methylphenidate; stimulants; pharmacotherapy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Warnke, A Univ Hosp, Dept Child & Adolescent Psychiat, EEG EP Mapping Lab,Fuechsleinstr 15, D-97080 Wurzburg, Germany Univ Hosp Fuechsleinstr 15 Wurzburg Germany D-97080 rg, Germany
Citazione:
K.E. Zillessen et al., "Changes of the brain electrical fields during the continuous performance test in attention-deficit hyperactivity disorder-boys depending on methylphenidate medication", CLIN NEU, 112(7), 2001, pp. 1166-1173

Abstract

Objective: The continuous performance test (CPT) is successfully applied to evaluate attentional performance in attention-deficit hyperactivity disorder (ADHD)-children. The aim of the present study was to investigate the changes of the topographic P300-features in relation to methylphenidate-medication and to different attentional processes in primer- and distractor-condition;;Methods: Twenty-one-channel-ERPs of 17 ADHD-boys were analyzed with reference-independent methods. Four quasi stable microstates within the time frames of conventional P100, P200, P3a and P3b components were identified by means of a data-driven segmentation procedure. Results: In segment 3 topographical assessment yielded a significant occipital and right-shift of the positive centroid, longer centroid distance andhigher amplitudes in primer- than in distracter conditions. MPH increased the amplitude and distance in primer and distractor-condition, without changing the topography. In segment 4 the electric fieldstrength of distractor-conditions collapsed, whereas the primer condition showed a strong fronto-parietallly oriented potential-field. There was a tendency to higher amplitudes due to MPH-medication. Conclusions: These results indicate a robust neurophysiologic differentiation of cognitive processes. MPH activates an early (P3a) covert attention process indicated by increased amplitudes and centroid. No effects were seenin later processes. Based on these effects, we propose to use the amplitude- and distance-increase in microstate 3 as an indicator of MPH efficacy inADHD-boys. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 25/01/20 alle ore 19:26:42