Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Treatment-induced neoangiogenesis in cerebral arteriovenous malformations
Autore:
Sure, U; Butz, N; Siegel, AM; Mennel, HD; Bien, S; Bertalanffy, H;
Indirizzi:
Univ Marburg, Neurochirurg Klin, D-35033 Marburg, Germany Univ Marburg Marburg Germany D-35033 rurg Klin, D-35033 Marburg, Germany Univ Marburg, Inst Neuropathol, Marburg, Germany Univ Marburg Marburg Germany arburg, Inst Neuropathol, Marburg, Germany Univ Marburg, Abt Neuroradiol, Marburg, Germany Univ Marburg Marburg Germany Marburg, Abt Neuroradiol, Marburg, Germany Univ Zurich, Neurol Klin, Zurich, Switzerland Univ Zurich Zurich Switzerland Zurich, Neurol Klin, Zurich, Switzerland
Titolo Testata:
CLINICAL NEUROLOGY AND NEUROSURGERY
fascicolo: 1, volume: 103, anno: 2001,
pagine: 29 - 32
SICI:
0303-8467(200104)103:1<29:TNICAM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; EXPRESSION; ANGIOGENESIS; DIFFERENTIATION; ANTIGEN; KI-67; MIB-1;
Keywords:
AVM; proliferation; neoangiogenesis; growth; immunohistochemistry;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
16
Recensione:
Indirizzi per estratti:
Indirizzo: Sure, U Univ Marburg, Neurochirurg Klin, Baldingerstr, D-35033 Marburg, Germany Univ Marburg Baldingerstr Marburg Germany D-35033 arburg, Germany
Citazione:
U. Sure et al., "Treatment-induced neoangiogenesis in cerebral arteriovenous malformations", CLIN NEUROL, 103(1), 2001, pp. 29-32

Abstract

We investigated the angiogenetic and proliferative activity of the endothelium of 30 consecutive surgical cases of AVM treated at our institution by immunohistochemical detection of the PCNA, MIB-1, Flk-1 and VEGF antibodies. Endothelial positive immunostaining was observed in 87% of the cases for PCNA, in 20% for MIB-1, and in 80% for Flk-1. Of 22 individuals treated with incomplete embolization prior to surgery, 17 showed an expression of VEGF(77%), but only two of the eight patients (25%) who were treated without prior embolization exhibited such an immunoreaction (P = 0.0086). The proliferation and growth of cerebral AVMs is documented by endothelial expressionof PCNA and MIB-1. The statistically significantly higher expression of VEGF in partially obliterated (embolized) AVMs is most likely caused by transient regional hypoxia within the AVM nidus that mediates neoangiogensis. Itpoints out the clinical relevance of a complete occlusion in order to avoid neovascularization associated with subsequent morbidity and mortality. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 22:50:50