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Titolo:
Pathogenesis of maternal-fetal syphilis revisited
Autore:
Wicher, V; Wicher, K;
Indirizzi:
New York State Dept Hlth, Wadsworth Ctr Labs & Res, Albany, NY 12201 USA New York State Dept Hlth Albany NY USA 12201 & Res, Albany, NY 12201 USA
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 3, volume: 33, anno: 2001,
pagine: 354 - 363
SICI:
1058-4838(20010801)33:3<354:POMSR>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL NEONATAL SYPHILIS; PALLIDUM SUBSP PALLIDUM; GROWTH FACTOR-BETA; T-CELL SUBSET; CONGENITAL-SYPHILIS; TREPONEMA-PALLIDUM; GUINEA-PIGS; BORRELIA-BURGDORFERI; IMMUNE RESPONSIVENESS; PREGNANT-WOMEN;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
116
Recensione:
Indirizzi per estratti:
Indirizzo: Wicher, V New York State Dept Hlth, Wadsworth Ctr Labs & Res, Empire StatePlaza,POB509, Albany, NY 12201 USA New York State Dept Hlth Empire State Plaza,POB 509 Albany NY USA 12201
Citazione:
V. Wicher e K. Wicher, "Pathogenesis of maternal-fetal syphilis revisited", CLIN INF D, 33(3), 2001, pp. 354-363

Abstract

Although congenital syphilis has been recognized for several centuries andan efficient treatment with penicillin became available more than a half-century ago, the disease is still with us. Inability to culture in vitro thecausative agent, Treponema pallidum, and the lack of an adequate animal model have prevented exploration of the various immunopathological events affecting the natural course of congenital infection. The purpose of this review is to analyze the disease in the context of recent knowledge acquired from human and experimental animals, particularly from the guinea pig model of congenital and neonatal syphilis, and to describe how the infection interacts with the maternal-fetal unit and how it is further modulated by the conceptus' ontogenic development. We also attempt to elucidate several old immunologic concepts and misconceptions that have remained unchallenged for too long.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 11:34:58