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Titolo:
Effect of cessation of highly active antiretroviral therapy during a discordant response: Implications for scheduled therapeutic interruptions
Autore:
Hawley-Foss, N; Mbisa, G; Lum, JJ; Pilon, AA; Angel, JB; Garber, G; Badley, AD;
Indirizzi:
Ottawa Hosp, Div Infect Dis, Res Inst, Ottawa, ON K1H 8L6, Canada Ottawa Hosp Ottawa ON Canada K1H 8L6 Res Inst, Ottawa, ON K1H 8L6, Canada Univ Ottawa, Ottawa Hosp, Res Inst, Ottawa, ON, Canada Univ Ottawa OttawaON Canada , Ottawa Hosp, Res Inst, Ottawa, ON, Canada
Titolo Testata:
CLINICAL INFECTIOUS DISEASES
fascicolo: 3, volume: 33, anno: 2001,
pagine: 344 - 348
SICI:
1058-4838(20010801)33:3<344:EOCOHA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; T-CELL RESPONSES; HIV PROTEASE INHIBITORS; IN-VIVO; VIROLOGICAL FAILURE; CUBIC MILLIMETER; INFECTED PERSONS; VIRAL FITNESS; RESISTANCE; VARIANTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Badley, AD Ottawa Hosp, Div Infect Dis, Res Inst, 501 Smyth Rd,Gen Campus,Ottawa, ONK1H 8L6, Canada Ottawa Hosp 501 Smyth Rd,Gen Campus Ottawa ON Canada K1H 8L6 da
Citazione:
N. Hawley-Foss et al., "Effect of cessation of highly active antiretroviral therapy during a discordant response: Implications for scheduled therapeutic interruptions", CLIN INF D, 33(3), 2001, pp. 344-348

Abstract

Although treatment with combination antiretroviral therapy leads to a reduction in the level of plasma viremia and an improvement in CD4 T cell countfor most patients, for a minority of patients, an improvement in CD4 T cell count occurs despite the failure of treatment to suppress viral replication. Recent reports suggest that these discordant improvements in CD4 T cellcount may last for months to years and are associated with improved clinical outcomes. In a retrospective observational study, we evaluated the effect of therapy cessation on 8 patients with discordant immunologic responses to therapy and found that improved CD4 T cell responses are dependent upon ongoing drug pressure. If antiretroviral agents that are likely to resuppress the virus are not available, we suggest that patients continue the therapy associated with immunologic improvement to maximize the clinical benefitof the discordant response.

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Documento generato il 05/04/20 alle ore 06:42:33