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Titolo:
Red blood cell aggregation measurements in whole blood and in fibrinogen solutions by different methods
Autore:
Marton, Z; Kesmarky, G; Vekasi, J; Cser, A; Russai, R; Horvath, B; Toth, K;
Indirizzi:
Univ Pecs, Sch Med, Dept Med 1, Div Cardiol, H-7643 Pecs, Hungary Univ Pecs Pecs Hungary H-7643 t Med 1, Div Cardiol, H-7643 Pecs, Hungary Univ Pecs, Sch Med, Dept Ophthalmol, Pecs, Hungary Univ Pecs Pecs Hungary iv Pecs, Sch Med, Dept Ophthalmol, Pecs, Hungary
Titolo Testata:
CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
fascicolo: 2, volume: 24, anno: 2001,
pagine: 75 - 83
SICI:
1386-0291(2001)24:2<75:RBCAMI>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; CORONARY-ARTERY DISEASE; HEMORHEOLOGICAL PARAMETERS; ERYTHROCYTE AGGREGATION; LIGHT TRANSMISSION; ANALYZER LORCA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Toth, K Univ Pecs, Sch Med, Dept Med 1, Div Cardiol, Ifjusag Ut 13, H-7643Pecs, Hungary Univ Pecs Ifjusag Ut 13 Pecs Hungary H-7643 H-7643 Pecs, Hungary
Citazione:
Z. Marton et al., "Red blood cell aggregation measurements in whole blood and in fibrinogen solutions by different methods", CL HEMORH M, 24(2), 2001, pp. 75-83

Abstract

Red blood cell (RBC) aggregation is an important component of whole blood viscosity, especially at low shear rates, and is the major cause of the non-Newtonian flow properties of normal blood. In different laboratories several methods are used to determine RBC aggregation, therefore the standardization of aggregation measurements is especially important for getting comparable results. Aggregation indices of 62 human blood samples were determinedby two different methods; LORCA (Laser-assisted Optical Rotational Cell Analyzer) and Myrenne aggregometers and related to plasma fibrinogen concentration. Our results show closer correlation values between RBC aggregation and fibrinogen concentration, when RBC aggregation was measured by LORCA (p < 0.001), although correlation could be revealed with Myrenne, when plasma fibrinogen level was less than 4.5 g/l. Correlation coefficient between aggregation indices measured by LORCA and Myrenne aggregometers was also closer below this fibrinogen level. In vitro examination of RBC aggregation in fibrinogen solutions showed that higher fibrinogen concentration results in higher RBC aggregation only up to a certain level similarly to that found in human whole blood samples. Our results show that plasma fibrinogen level has an important, concentration dependent effect on RBC aggregation in human blood, but above a certain level it may not cause further aggregate formation.

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Documento generato il 23/01/20 alle ore 06:17:53