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Titolo:
Viral load in breast milk correlates with transmission of human cytomegalovirus to preterm neonates, but lactoferrin concentrations do not
Autore:
van der Strate, BWA; Harmsen, MC; Schafer, P; Swart, PJ; The, TH; Jahn, G; Speer, CP; Meijer, DKF; Hamprecht, K;
Indirizzi:
Univ Groningen, Inst Drug Explorat GUIDE, Dept Pharmacokinet & Drug Delivery, Ctr Pharm, NL-9713 AV Groningen, Netherlands Univ Groningen GroningenNetherlands NL-9713 AV V Groningen, Netherlands Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Dept Clin Immunol,NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Groningen Hosp, Groningen Univ Inst Drug Explorat, Dept Pathol & Lab Med, NL-9713 GZ Groningen, Netherlands Univ Groningen Hosp Groningen Netherlands NL-9713 GZ ningen, Netherlands Univ Hamburg, Krankenhaus Eppendorf, Inst Med Mikrobiol & Immunol, D-20246Hamburg, Germany Univ Hamburg Hamburg Germany D-20246 & Immunol, D-20246Hamburg, Germany Univ Tubingen Hosp, Inst Med Virol & Epidemiol Viral Dis, D-72076 Tubingen, Germany Univ Tubingen Hosp Tubingen Germany D-72076 s, D-72076 Tubingen, Germany Univ Wurzburg, Childrens Hosp, D-97080 Wurzburg, Germany Univ Wurzburg Wurzburg Germany D-97080 s Hosp, D-97080 Wurzburg, Germany
Titolo Testata:
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY
fascicolo: 4, volume: 8, anno: 2001,
pagine: 818 - 821
SICI:
1071-412X(200107)8:4<818:VLIBMC>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PERIPHERAL-BLOOD LEUKOCYTES; IN-VITRO; POTENT ACTIVITY; INFECTION; PROTEINS; LYSOZYME; WHEY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: van der Strate, BWA Univ Groningen, Inst Drug Explorat GUIDE, Dept Pharm &Drug Delivery, Ctr Pharm, Ant Deusinglaan 1, NL-9713 AV Groningen, Netherlands Univ Groningen Ant Deusinglaan 1 Groningen Netherlands NL-9713 AV
Citazione:
B.W.A. van der Strate et al., "Viral load in breast milk correlates with transmission of human cytomegalovirus to preterm neonates, but lactoferrin concentrations do not", CL DIAG LAB, 8(4), 2001, pp. 818-821

Abstract

In vitro, lactoferrin (LF) strongly inhibits human cytomegalovirus (HCMV),which led us to hypothesize that in vivo HCMV might also be inhibited in secretions with high LF concentrations. In breast milk, high viral loads observed as high viral DNA titers tended to coincide with higher LF levels. However, the LF Levels did not correlate to virus transmission to preterm infants. The viral load in the transmitting group was highest compared to the nontransmitting group. We conclude that viral load in breast milk is an important factor for transmission of the virus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 11:33:38