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Titolo:
Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension
Autore:
Rhaleb, NE; Peng, HM; Yang, XP; Liu, YH; Mehta, D; Ezan, E; Carretero, OA;
Indirizzi:
Henry Ford Hosp, Hypertens & Vasc Res Div, Detroit, MI 48202 USA Henry Ford Hosp Detroit MI USA 48202 Vasc Res Div, Detroit, MI 48202 USA CEA, Serv Pharmacol & Immunol, Gif Sur Yvette, France CEA Gif Sur YvetteFrance v Pharmacol & Immunol, Gif Sur Yvette, France
Titolo Testata:
CIRCULATION
fascicolo: 25, volume: 103, anno: 2001,
pagine: 3136 - 3141
SICI:
0009-7322(20010626)103:25<3136:LEONOL>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING ENZYME; HEMATOPOIETIC STEM-CELLS; MYOCARDIAL FIBROSIS; TETRAPEPTIDE ACSDKP; IN-VIVO; RENOVASCULAR HYPERTENSION; GRIFFONIA-SIMPLICIFOLIA; NEGATIVE REGULATOR; MOUSE-TISSUES; PLASMA-LEVEL;
Keywords:
angiotensin; hypertension, renal; blood pressure; inhibitors; collagen; myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Rhaleb, NE Henry Ford Hosp, Hypertens & Vasc Res Div, Educ & Res Suite 7015,2799 W Grand Blvd, Detroit, MI 48202 USA Henry Ford Hosp Educ & Res Suite7015,2799 W Grand Blvd Detroit MI USA 48202
Citazione:
N.E. Rhaleb et al., "Long-term effect of N-acetyl-seryl-aspartyl-lysyl-proline on left ventricular collagen deposition in rats with 2-kidney, 1-clip hypertension", CIRCULATION, 103(25), 2001, pp. 3136-3141

Abstract

Background-N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) is a natural inhibitor of pluripotent hematopoietic stem cell proliferation. Ac-SDKP plasma concentration is increased 5-fold after angiotensin-converting enzyme inhibition. Here we studied the effect of Ac-SDKP on monocyte/macrophage infiltration, fibroblast proliferation, and collagen deposition in the rat heartin renovascular hypertension. Methods and Results-We investigated whether long-term Ac-SDKP administration would prevent left ventricular (LV) hypertrophy and interstitial collagen deposition in rats with 2-kidney, 1-clip (2K-1C) hypertension. Ac-SDKP (400 mug.kg(-1).d(-1)) did not affect development of hypertension. Mean bloodpressure was similar in rats with 2K-1C hypertension whether they were given vehicle or Ac-SDKP and was higher than in controls. Both LV weight and cardiomyocyte size were significantly increased in rats with 2K-1C hypertension compared with controls and were unaffected by Ac-SDKP. Proliferating cell nuclear antigen- and monocyte/macrophage-positive cells were increased in the LV of 2K-1C hypertensive rats; this increase was significantly blunted by Ac-SDKP (P<0.001). LV interstitial collagen fraction was also increased in 2K-1C hypertensive fats given vehicle (10.1<plus/minus>0.8%) compared with sham (5.3 +/-0.1%, P<0.0001), and this increase was prevented by Ac-SDKP (5.4<plus/minus>0.4%, P<0.001). Conclusions-Ac-SDKP inhibited monocyte/macrophage infiltration, cell proliferation, and collagen deposition in the LV of hypertensive rats without affecting blood pressure or cardiac hypertrophy, suggesting that it may be partly responsible for the cardioprotective effect of angiotensin-converting enzyme inhibitors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 19:51:43