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Titolo:
Thrombogenic alleles, Escherichia coli O157 : H7 infections, and hemolyticuremic syndrome
Autore:
Sprouse, JT; Wong, CS; Chandler, WL; Williams, GD; Watkins, SL; Tarr, PI;
Indirizzi:
Childrens Hosp & Med Ctr, Div Gastroenterol, Seattle, WA 98105 USA Childrens Hosp & Med Ctr Seattle WA USA 98105 erol, Seattle, WA 98105 USA Childrens Hosp & Med Ctr, Div Anesthesiol, Seattle, WA 98105 USA ChildrensHosp & Med Ctr Seattle WA USA 98105 siol, Seattle, WA 98105 USA Childrens Hosp & Med Ctr, Div Nephrol, Seattle, WA 98105 USA Childrens Hosp & Med Ctr Seattle WA USA 98105 hrol, Seattle, WA 98105 USA Univ Washington, Sch Med, Dept Lab Med, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Lab Med, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Pathol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pathol, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Pediat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 , Dept Pediat, Seattle, WA 98195 USA Univ Washington, Sch Med, Dept Anesthesiol, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 t Anesthesiol, Seattle, WA 98195 USA
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 283 - 288
SICI:
0957-5235(200106)12:4<283:TAECO:>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACTIVATOR INHIBITOR-1 PAI-1; FACTOR-V; PLASMINOGEN-ACTIVATOR-INHIBITOR-1 GENE; VENOUS THROMBOEMBOLISM; RENAL HISTOPATHOLOGY; ENDOTHELIAL-CELLS; IN-VITRO; POLYMORPHISM; PROTHROMBIN; COAGULATION;
Keywords:
factor V Leiden; hemolytic uremic syndrome; methylenetetrahydrofolate reductase gene; plasminogen activator inhibitor-1 promoter; prothrombin gene;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Tarr, PI Childrens Hosp & Med Ctr, Div Gastroenterol, CH-24,4800 Sand Point Way NE,Seattle, WA 98105 USA Childrens Hosp & Med Ctr CH-24,4800 Sand Point Way NE Seattle WA USA 98105
Citazione:
J.T. Sprouse et al., "Thrombogenic alleles, Escherichia coli O157 : H7 infections, and hemolyticuremic syndrome", BL COAG FIB, 12(4), 2001, pp. 283-288

Abstract

Hemolytic uremic syndrome (HUS) of childhood most commonly follows gastrointestinal infection with Escherichia coli O157:H7. This pathogen elaboratesShiga toxins that are believed to cause microvascular injury and to trigger a thrombogenic response. The exact mechanisms leading to variable diseasemanifestations are unknown. Allelic variation in genes encoding selected coagulation factors and inhibitors of fibrinolysis were examined to determine whether or not a causal relationship exists between hypercoagulability and the development of HUS. No correlation between the thrombogenic factor V (G1691A), factor II (G20210A), methylenetetrahydrofolate reductase (C677T) or the plasminogen activator inhibitor (PAI)-1 promotor (4G/5G) genotypes and the risk of infection with E. coli O157:H7, or the risk of development of HUS among infected patients, was found. Serum PAI-1 levels did not correlate with the PAI-1 genotype. We conclude that the alleles studied are not major risk factors for the acquisition of E. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 08:55:39