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Titolo:
Depressed plasma activity of plasminogen or alpha 2 plasmin inhibitor is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation
Autore:
Asakura, H; Ontachi, Y; Mizutani, T; Kato, M; Ito, T; Saito, M; Morishita, E; Yamazaki, M; Suga, Y; Miyamoto, KI; Nakao, S;
Indirizzi:
Kanazawa Univ, Sch Med, Dept Internal Med 3, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Kanazawa Ishikawa Japan 9208641 wa, Ishikawa 9208641, Japan Kanazawa Univ, Sch Med, Hosp Pharm, Kanazawa, Ishikawa 920, Japan KanazawaUniv Kanazawa Ishikawa Japan 920 , Kanazawa, Ishikawa 920, Japan
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 275 - 281
SICI:
0957-5235(200106)12:4<275:DPAOPO>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE PROMYELOCYTIC LEUKEMIA; MOLECULAR MARKERS; ANTITHROMBIN-III; ORGAN FAILURE; PROTEIN-C; FIBRINOLYSIS; SUBSTRATE; SHOCK; ACID; ANTIPLASMIN;
Keywords:
disseminated intravascular coagulation; sepsis; plasminogen; alpha 2 plasmin inhibitor; consumption coagulopathy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Asakura, H Kanazawa Univ, Sch Med, Dept Internal Med 3, Takaramachi 13-1, Kanazawa, Ishikawa 9208641, Japan Kanazawa Univ Takaramachi 13-1 Kanazawa Ishikawa Japan 9208641
Citazione:
H. Asakura et al., "Depressed plasma activity of plasminogen or alpha 2 plasmin inhibitor is not due to consumption coagulopathy in septic patients with disseminated intravascular coagulation", BL COAG FIB, 12(4), 2001, pp. 275-281

Abstract

We have attempted to determine whether depressed plasma plasminogen and alpha2 plasmin inhibitor (or alpha2 antiplasmin) activity is, as a result of consumption coagulopathy, a specific finding of disseminated intravascular coagulation (DIC) in septic patients. The hemostatic parameters of 139 septic patients (68 with DIC and 71 without DIG) were analyzed. Among the groupas a whole, plasma activities of plasminogen and alpha2 plasmin inhibitor were significantly depressed in septic patients with DIC relative to those without DIC (P < 0.01 and P < 0.05, respectively). Notably, a significant correlation was observed between plasma levels of albumin and plasminogen activity, as well as between plasma levels of albumin and alpha2 plasmin inhibitor activity both in septic patients with DIC and those without DIG. However, no significant correlation was observed between plasma levels of plasmin-alpha2 plasmin inhibitor complex (PIC) and plasminogen activity, nor between PIC and alpha2 plasmin inhibitor activity either in septic patients with DIC or those without DIG. We concluded that depressed activity of plasminogen or alpha2 plasmin inhibitor is not as a result of consumption coagulopathy, but rather a result of low synthetic function of the liver in septicpatients with DIG. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 20:49:58