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Titolo:
Maximal endothelial tissue plasminogen activator release is not impaired in patients with acute coronary syndromes before heparin treatment
Autore:
Olivotti, L; Spallarossa, P; Piana, A; Iannone, A; Rossettin, P; Ghigliotti, G; Armani, U; Barsotti, A; Brunelli, C;
Indirizzi:
Univ Genoa, Dept Cardiol, Div Cardiol, I-16132 Genoa, Italy Univ Genoa Genoa Italy I-16132 ardiol, Div Cardiol, I-16132 Genoa, Italy Univ Genoa, Dept Internal Med, Genoa, Italy Univ Genoa Genoa ItalyUniv Genoa, Dept Internal Med, Genoa, Italy
Titolo Testata:
BLOOD COAGULATION & FIBRINOLYSIS
fascicolo: 4, volume: 12, anno: 2001,
pagine: 261 - 267
SICI:
0957-5235(200106)12:4<261:METPAR>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; UNSTABLE ANGINA-PECTORIS; RAPID INHIBITOR; ARTERY DISEASE; PAI-1 COMPLEX; HEART-DISEASE; PLASMA-LEVELS; T-PA; FIBRINOLYSIS; ISCHEMIA;
Keywords:
unstable angina; myocardial infarction; heparin; fibrinolysis; blood coagulation; tissue plasminogen activator; plasminogen activator inhibitor-1; vascular endothelium; fibrin-fibrinogen degradation products; prothrombin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Olivotti, L Univ Genoa, Dept Cardiol, Div Cardiol, Viale Benedetto XV,6, I-16132 Genoa, Italy Univ Genoa Viale Benedetto XV,6 Genoa Italy I-16132 oa, Italy
Citazione:
L. Olivotti et al., "Maximal endothelial tissue plasminogen activator release is not impaired in patients with acute coronary syndromes before heparin treatment", BL COAG FIB, 12(4), 2001, pp. 261-267

Abstract

Procoagulant and fibrinolytic disturbances are described in patients with acute coronary syndromes (ACS), but whether defective maximal tissue plasminogen activator (t-PA) release from the endothelium is also present is still controversial. Previous studies did not take into consideration the contribution of heparin, which strongly affects fibrinolysis. Accordingly, in this study, we measured maximal t-PA release in patients with ACS before, during, and after heparin treatment. Maximal t-PA release was measured by the venous occlusion test in 38 hospitalized patients with confirmed ACS (18 acute myocardial infarctions and 20 unstable anginas) before starting heparin, during heparin treatment, and 4 and 12 h after discontinuation. Plasma plasminogen activator inhibitor type 1 (PAI-1), D-dimer and prothrombin fragment F1 + 2 were also measured. Eighteen age-matched subjects with no evidence of coronary disease were used as controls. At admission, patients showedsignificantly higher plasma levels of t-PA, PAI-1, and F1 + 2 than controls. Before heparin, maximal t-PA release was similar in patients and controls. Heparin treatment was associated with a significant increase of plasma t-PA, while it did not affect maximal t-PA release. Coagulative and fibrinolytic disturbances are present in patients with ACS, but these do not include maximal t-PA release. Among our patients, maximal t-PA release appears stable over time and is not affected by heparin treatment. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 13:15:13