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Titolo:
Low frequency of BCL-2/J(H) translocation in peripheral blood lymphocytes of healthy Japanese individuals
Autore:
Yasukawa, M; Bando, S; Dolken, G; Sada, E; Yakushijin, Y; Fujita, S; Makino, H;
Indirizzi:
Ehime Univ, Sch Med, Dept Internal Med 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Shigenobu, Ehime 7910295, Japan Ehime Univ, Sch Med, Dept Clin Lab Med, Shigenobu, Ehime, Japan Ehime Univ Shigenobu Ehime Japan t Clin Lab Med, Shigenobu, Ehime, Japan Univ Greifswald, Klin & Poliklin Innere Med C, Greifswald, Germany Univ Greifswald Greifswald Germany in Innere Med C, Greifswald, Germany
Titolo Testata:
BLOOD
fascicolo: 2, volume: 98, anno: 2001,
pagine: 486 - 488
SICI:
0006-4971(20010715)98:2<486:LFOBTI>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NON-HODGKINS-LYMPHOMAS; CHROMOSOMAL BREAKPOINT; FOLLICULAR LYMPHOMA; B-CELLS; T(14-18); GENE; INVOLVEMENT; T(14,18); DISEASES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yasukawa, M Ehime Univ, Sch Med, Dept Internal Med 1, Shigenobu, Ehime 7910295, Japan Ehime Univ Shigenobu Ehime Japan 7910295 Ehime 7910295, Japan
Citazione:
M. Yasukawa et al., "Low frequency of BCL-2/J(H) translocation in peripheral blood lymphocytes of healthy Japanese individuals", BLOOD, 98(2), 2001, pp. 486-488

Abstract

The incidence of follicular lymphoma differs significantly between white and Japanese individuals. Translocation between the BCL-2 and immunoglobulinheavy chain genes is detected in 85% to 90% of all follicular lymphomas inwhites. Recently, BCL-2/J(H) translocation was detected in peripheral blood lymphocytes from more than 50% of healthy white individuals. To clarify the reason for the difference in incidence of follicular lymphoma between whites and Japanese, the frequency of BCL-2/JH translocation in peripheral blood lymphocytes of healthy Japanese individuals was compared with that of German individuals. The prevalence of BCL-2/JH translocation in Japanese adults appeared to be significantly lower than that in German adults. The present data suggest that the low frequency of BCL-2/J(H) translocation in the Japanese general population may be one of the major reasons for the difference in incidence of follicular lymphoma between whites and Japanese. (C) 2001 by The American Society of Hematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 21:09:04