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Titolo:
A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes
Autore:
Newton, PN; Chotivanich, K; Chierakul, W; Ruangveerayuth, R; Teerapong, P; Silamut, K; Looareesuwan, S; White, NJ;
Indirizzi:
Mahidol Univ, Fac Trop Med, Bangkok 10400, Thailand Mahidol Univ BangkokThailand 10400 ac Trop Med, Bangkok 10400, Thailand John Radcliffe Hosp, Nuffield Dept Clin Med, Ctr Trop Med, Oxford, EnglandJohn Radcliffe Hosp Oxford England n Med, Ctr Trop Med, Oxford, England Mae Sot Hosp, Dept Med, Tak Province, Thailand Mae Sot Hosp Tak ProvinceThailand sp, Dept Med, Tak Province, Thailand Mahidol Univ, Fac Pharm, Dept Pharmacol, Bangkok 10700, Thailand Mahidol Univ Bangkok Thailand 10700 t Pharmacol, Bangkok 10700, Thailand
Titolo Testata:
BLOOD
fascicolo: 2, volume: 98, anno: 2001,
pagine: 450 - 457
SICI:
0006-4971(20010715)98:2<450:ACOTIV>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BLOOD-CELL DEFORMABILITY; MALARIA PARASITES; ANEMIA; CLEARANCE; SURVIVAL; DESTRUCTION; PF155/RESA; MEROZOITES; SPECTRIN; MEMBRANE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: White, NJ Mahidol Univ, Fac Trop Med, 420-6 Rajvithi Rd, Bangkok 10400, Thailand Mahidol Univ 420-6 Rajvithi Rd Bangkok Thailand 10400 Thailand
Citazione:
P.N. Newton et al., "A comparison of the in vivo kinetics of Plasmodium falciparum ring-infected erythrocyte surface antigen-positive and -negative erythrocytes", BLOOD, 98(2), 2001, pp. 450-457

Abstract

Ring-infected erythrocyte surface antigen (RESA)-positive, Plasmodium falciparum-negative red blood cells (RBCs) are cells from which the malaria parasite has been removed by the host without the destruction of the erythrocyte ("pitting"), The survival of RESA-RBCs in vivo was assessed in 14 severeand 6 uncomplicated falciparum malaria patients. The mean RESA-RBC life of183 hours (95% confidence interval [CI], 136-246) was longer than the median parasite clearance time of 66 hours (range, 30-108 hours) but shorter than the mean red cell life of 1027 hours (95% CI, 840-1213) (P = .0004), with a median ratio of 0.2:1.0 (range, 0.1-0.7). The estimated median percentage of parasites pitted-body transit was 0.003% (range, 0.001%-0.05%). The rate of rise of the RESA-RBC count during the first 24 hours after antimalarial treatment was significantly faster (P = .036) and the subsequent RESA-RBC survival significantly shorter (P = .017) after treatment with an artemisinin derivative than after treatment with quinine, Parasitization of red cells leads to changes in the erythrocyte that shorten their survival even if the parasite is removed subsequently. (C) 2001 by The American Society ofHematology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 10:58:47