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Titolo:
The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review
Autore:
Bearden, CE; Hoffman, KM; Cannon, TD;
Indirizzi:
Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA Univ Penn Philadelphia PA USA 19104 Psychiat, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA Childrens Hosp Philadelphia Philadelphia PA USA 19104 lphia, PA 19104 USA Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90024 USA Univ CalifLos Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
BIPOLAR DISORDERS
fascicolo: 3, volume: 3, anno: 2001,
pagine: 106 - 150
SICI:
1398-5647(200106)3:3<106:TNANOB>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; MAJOR AFFECTIVE-DISORDERS; LATERAL VENTRICULAR ENLARGEMENT; STRUCTURAL BRAIN ABNORMALITIES; SUBGENUAL PREFRONTAL CORTEX; CONTINUOUS PERFORMANCE-TEST; WHITE-MATTER ABNORMALITIES; MANIC-DEPRESSIVE PATIENTS; MINOR PHYSICAL ANOMALIES; TEMPORAL-LOBE STRUCTURE;
Keywords:
affective disorders; bipolar disorder; cognition; depression; mania; neuroanatomy; neuroimaging; neuropsychology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
202
Recensione:
Indirizzi per estratti:
Indirizzo: Bearden, CE Vet Adm Med Ctr, Dept Psychol, 3350 La Jolla Village Dr, La Jolla, CA 92161 USA Vet Adm Med Ctr 3350 La Jolla Village Dr La Jolla CA USA 92161
Citazione:
C.E. Bearden et al., "The neuropsychology and neuroanatomy of bipolar affective disorder: a critical review", BIPOL DIS, 3(3), 2001, pp. 106-150

Abstract

Objectives: To present a comprehensive review of the existing neuropsychological and neuroinlaging literature on bipolar affective disorder. This review critically evaluates two common conceptions regarding the neuropsychology of bipolar disorder: 1) that, in contrast to schizophrenia, bipolar affective disorder is not associated with general cognitive impairment independent of illness episodes, and 2) relative right hemisphere (RH) dysfunction is implicated in bipolar illness patients, supported by reports of relatively greater impairment in visuospatial functioning, lateralization abnormalities, and mania secondary to RH lesions. Methods: The major computerized databases (Medline and PSYCInfo) were consulted in order to conduct a comprehensive, integrated review of the literature on the neuropsychology and neuroanatomy of bipolar disorder. Articles meeting specified criteria were included in this review. Results: In a critical evaluation of the above notions, this paper determines that: 1) while there is little evidence for selective RH dysfunction, significant cognitive impairment may be present in bipolar illness, particularly in a subgroup of chronic, elderly or multiple-episode patients, suggesting a possible toxic disease process, and 2) the underlying functional correlate of these cognitive deficits may be white matter lesions ('signal hyperintensities') in the frontal lobes and basal ganglia, regions critical for executive function, attention, speeded information processing, learning and memory, and affect regulation, While this hypothesized neural correlate of cognitive impairment in bipolar disorder is speculative, preliminary functional neuroimaging evidence supports the notion of frontal and subcortical hypometabolism in bipolar illness,Conclusions: The etiology of the structural brain abnormalities commonly seen in bipolar illness, and their corresponding functional deficits, remains unknown. It is possible that neurodevelopmental anomalies may play a role, and it remains to be determined whether there is also some pathophysiological progression that occurs with repeated illness episodes. More research is needed on first-episode patients, relatives of bipolar probands, and within prospective longitudinal paradigms in order to isolate disease-specificimpairments and genetic markers of neurocognitive function in bipolar disorder.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:47:35