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Titolo:
Influence of solvent and configuration of residues at positions 2 and 3 ondistance and mobility of pharmacophore groups at positions 1 and 4 in cyclic enkephalin analogues
Autore:
Malicka, J; Groth, M; Czaplewski, C; Karolczak, J; Liwo, A; Wiczk, W;
Indirizzi:
Univ Gdansk, Fac Chem, Gdansk, Poland Univ Gdansk Gdansk PolandUniv Gdansk, Fac Chem, Gdansk, Poland Adam Mickiewicz Univ, Fac Phys, Quantum Elect Lab, PL-61614 Poznan, PolandAdam Mickiewicz Univ Poznan Poland PL-61614 Lab, PL-61614 Poznan, Poland
Titolo Testata:
BIOPOLYMERS
fascicolo: 3, volume: 59, anno: 2001,
pagine: 180 - 190
SICI:
0006-3525(200109)59:3<180:IOSACO>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESONANCE ENERGY-TRANSFER; STAPHYLOCOCCAL NUCLEASE MUTANT; YEAST PHOSPHOGLYCERATE KINASE; PANCREATIC TRYPSIN-INHIBITOR; 4-WAY DNA JUNCTION; CONFORMATIONAL FLEXIBILITY; TRIANTENNARY GLYCOPEPTIDE; DOMAIN FLUOROMETRY; ORIENTATION FACTOR; ANISOTROPY DECAYS;
Keywords:
enkephalin analogues; time-resolved fluorescence spectroscopy; distance distribution; amino acid configuration;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Wiczk, W Univ Gdansk, Fac Chem, Sobieskiego 1880-952, Gdansk, Poland Univ Gdansk Sobieskiego 1880-952 Gdansk Poland , Gdansk, Poland
Citazione:
J. Malicka et al., "Influence of solvent and configuration of residues at positions 2 and 3 ondistance and mobility of pharmacophore groups at positions 1 and 4 in cyclic enkephalin analogues", BIOPOLYMERS, 59(3), 2001, pp. 180-190

Abstract

The analgesic activity of opioid peptides is mainly connected with their affinity and selectivity for the mu -receptors. The biological activity of cyclic opioid analogues depends on mutual orientation and conformational freedom of aromatic pharmacophore groups at positions 1 and 4 The distance anddistance distributions between chromophores at positions 1 [Phe(p-NO2), p-nitrophenylalanine] and 4 [Nal, beta-(2-naphthyl)alanine], which constitutean energy donor-acceptor pair, were calculated based on measured fluorescence intensity decays of a donor (Nal). The influence of the solvent and configuration of the residues at position 2 and 3 on donor-acceptor distance distribution and mobility of pharmacophore groups at position 1 and 4 in cyclic enkephalin analogues are discussed. (C) 2001 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:35:49