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Titolo:
Synthesis of N-1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors
Autore:
Mukhopadhyaya, JK; Kozikowski, AP; Grajkowska, E; Pshenichkin, S; Wroblewski, JT;
Indirizzi:
Georgetown Univ, Med Ctr, Drug Discovery Program, Dept Neurol, Washington,DC 20007 USA Georgetown Univ Washington DC USA 20007 t Neurol, Washington,DC 20007 USA Georgetown Univ, Med Ctr, Dept Pharmacol, Washington, DC 20007 USA Georgetown Univ Washington DC USA 20007 armacol, Washington, DC 20007 USA
Titolo Testata:
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
fascicolo: 14, volume: 11, anno: 2001,
pagine: 1919 - 1924
SICI:
0960-894X(20010723)11:14<1919:SONAO(>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PHARMACOLOGICAL CHARACTERIZATION; RAT HIPPOCAMPUS; MGLUR AGONIST; LY354740; BIOLOGY; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Kozikowski, AP Georgetown Univ, Med Ctr, Drug Discovery Program, Dept Neurol, 3900 Reservoir Rd,NW, Washington, DC 20007 USA Georgetown Univ 3900 Reservoir Rd,NW Washington DC USA 20007
Citazione:
J.K. Mukhopadhyaya et al., "Synthesis of N-1-substituted analogues of (2R,4R)-4-amino-pyrrolidine-2,4-dicarboxylic acid as agonists, partial agonists, and antagonists of group II metabotropic glutamate receptors", BIOORG MED, 11(14), 2001, pp. 1919-1924

Abstract

The chemical synthesis of a series of N-1-substituted derivatives of (2R,4R)-4-aminopyrrolidine-2,4-dicarboxylic acid [(2R,4R)-APDC] as constrained analogues of gamma -substituird glutamic acids is described. Appropriate substitution of the N-1-position results in agonist, partial agonist, or antagonist activity at mGluR(2), mGluR(3), and/or mGluR6. (C) 2001 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:35:57