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Titolo:
Pathophysiology of immune-mediated (type 1) diabetes mellitus - Potential for immunotherapy
Autore:
Abel, M; Krokowski, M;
Indirizzi:
Med Univ Lodz, Inst Paediat, Immunopathol Lab, PL-91738 Lodz, Poland Med Univ Lodz Lodz Poland PL-91738 munopathol Lab, PL-91738 Lodz, Poland
Titolo Testata:
BIODRUGS
fascicolo: 5, volume: 15, anno: 2001,
pagine: 291 - 301
SICI:
1173-8804(2001)15:5<291:POI(1D>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMIC-ACID DECARBOXYLASE; REGULATORY T-CELLS; PANCREATIC BETA-CELLS; ANTIGEN-PRESENTING CELLS; FIRST-DEGREE RELATIVES; GROWTH-FACTOR-BETA; NOD MICE; ORAL TOLERANCE; HIGH-RISK; CELLULAR-IMMUNITY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
140
Recensione:
Indirizzi per estratti:
Indirizzo: Abel, M Med Univ Lodz, Inst Paediat, Immunopathol Lab, Sporna 36-50, PL-91738 Lodz, Poland Med Univ Lodz Sporna 36-50 Lodz Poland PL-91738 1738 Lodz, Poland
Citazione:
M. Abel e M. Krokowski, "Pathophysiology of immune-mediated (type 1) diabetes mellitus - Potential for immunotherapy", BIODRUGS, 15(5), 2001, pp. 291-301

Abstract

Type 1 diabetes mellitus is a chronic T cell-mediated disease resulting from autoimmune destruction of pancreatic p-cells. This process leads to progressive and irreversible failure of insulin secretion. Development of the disease involves both genetic and environmental factors. Genetic predisposition is mainly connected with the human leucocyte antigen (HLA) region, which encodes structures responsible for antigen presentation. A comprehensive molecular understanding of the pathogenesis of the disease is essential forthe design of rational and well tolerated means of prevention. This paper describes recent experimental and clinical findings and elucidates the current possibilities for immunotherapy of type 1 diabetes. The nature of breakdown of self-tolerance and the mechanisms involved in its recovery are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 01:19:23