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Titolo:
Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice
Autore:
Vandenput, L; Ederveen, AGH; Erben, RG; Stahr, K; Swinnen, JV; Van Herck, E; Verstuyf, A; Boonen, S; Bouillon, R; Vanderschueren, D;
Indirizzi:
Lab Expt Geneeskunde Endocrinol Onderwijs Navorsi, B-3000 Louvain, BelgiumLab Expt Geneeskunde Endocrinol Onderwijs Navorsi Louvain Belgium B-3000 Katholieke Univ Leuven, Ctr Metab Bone Dis, Louvain, Belgium Katholieke Univ Leuven Louvain Belgium Metab Bone Dis, Louvain, Belgium NV Organon, Dept Pharmacol Res & Dev, NL-5340 BH Oss, Netherlands NV Organon Oss Netherlands NL-5340 BH & Dev, NL-5340 BH Oss, Netherlands Univ Munich, Inst Physiol Physiol Chem & Anim Nutr, Munich, Germany Univ Munich Munich Germany ol Physiol Chem & Anim Nutr, Munich, Germany
Titolo Testata:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
fascicolo: 1, volume: 285, anno: 2001,
pagine: 70 - 76
SICI:
0006-291X(20010706)285:1<70:TPOBLI>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
AGED MALE-RATS; AROMATASE DEFICIENCY; MINERAL DENSITY; ANDROGEN DEFICIENCY; SEX STEROIDS; MEN; OSTEOPOROSIS; METABOLISM; MUTATION; MASS;
Keywords:
androgens; estrogens; estrogen receptor-alpha; mice; orchidectomy; bone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Vanderschueren, D Lab Expt Geneeskunde Endocrinol Onderwijs Navorsi, Campus Gasthuisberg,Herestr 49, B-3000 Louvain, Belgium Lab Expt Geneeskunde Endocrinol Onderwijs Navorsi Campus Gasthuisberg,Herestr 49 Louvain Belgium B-3000
Citazione:
L. Vandenput et al., "Testosterone prevents orchidectomy-induced bone loss in estrogen receptor-alpha knockout mice", BIOC BIOP R, 285(1), 2001, pp. 70-76

Abstract

To examine the role of the estrogen receptor-alpha (ER alpha) during male skeletal development, bone density and structure of aged ER alpha KO mice and wild-type (WT) littermates were analyzed and skeletal changes in response to sex steroid deficiency and replacement were also studied. In comparison to WT, ER alpha KO mice had smaller and thinner bones, arguing for a direct role of ER alpha to obtain full skeletal size in male mice. However, male ER alpha KO mice had significantly more trabecular bone as assessed both by pQCT and histomorphometry, indicating that ER alpha is not essential to maintain cancellous bone mass. Six weeks following orchidectomy (ORX), bothWT and ER alpha KO mice showed high-turnover osteoporosis as revealed by increases in serum osteocalcin and decreases in trabecular (-38% and -58% inWT and ER alpha KO, respectively) and cortical bone density (-5% and -4% in WT and ER alpha KO, respectively). Administration of testosterone propionate (T, 5 mg/kg/day) completely prevented bone loss both in ER alpha KO andin WT mice. As expected, estradiol (E2, 60 mug/kg/day) replacement did notprevent cancellous bone loss in ORX ER alpha KO mice. However, E2 stimulated bone formation at the endocortical surface in ORX ER alpha KO, suggesting that osteoblasts may respond to nonER alpha -mediated estrogen action, Inconclusion, although functional ER alpha may play a significant role during male skeletal development, this receptor does not seem essential for androgen-mediated skeletal maintenance in older male mice. (C) 2001 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 02:47:06