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Titolo:
Phentolamine suppresses the increase in arteriolar vasomotion frequency due to systemic hypoxia in hamster skeletal muscle microcirculation
Autore:
Colantuoni, A; Bertuglia, S; Marchiafava, PL;
Indirizzi:
Univ Pisa, Dept Biochem & Physiol, I-56127 Pisa, Italy Univ Pisa Pisa Italy I-56127 Dept Biochem & Physiol, I-56127 Pisa, Italy
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 90, anno: 2001,
pagine: 148 - 151
SICI:
1566-0702(20010720)90:1-2<148:PSTIIA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT; VENULES;
Keywords:
systemic hypoxia; arterioles; vasomotion; phentolamine; sympathetic nervous discharge;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Colantuoni, A Univ Pisa, Dept Biochem & Physiol, Via S Zeno 31, I-56127 Pisa, Italy Univ Pisa Via S Zeno 31 Pisa Italy I-56127 6127 Pisa, Italy
Citazione:
A. Colantuoni et al., "Phentolamine suppresses the increase in arteriolar vasomotion frequency due to systemic hypoxia in hamster skeletal muscle microcirculation", AUTON NEURO, 90(1-2), 2001, pp. 148-151

Abstract

Systemic hypoxia (8%, 11% and 15% oxygen gas mixture inspiration) has beenshown to increase the frequency of arteriolar rhythmic diameter changes inhamster skeletal muscle microcirculation. The effects of phentolamine on vasomotion frequency during systemic hypoxia were studied in Syrian hamstersimplanted with a plastic chamber in the dorsum skin. Phentolamine(50 mug/100 g body wt.) was injected intravenously before the 20-min exposure to 11%oxygen gas mixture. The microvessels were studied with a fluorescent microscopy technique, using fluorescein isothiocyanate bound to dextran (mol. wt. 150,000) as a tracer. Vessel diameters were measured with a: shearing method. Fourier transform and autoregressive modeling were used to assess the time variant features of diameter changes. Under baseline conditions, the arterioles were characterized by rhythmic diameter changes with fundamental frequency related to vessel size. The terminal branchings were dominated by order 3 vessel activity (frequency: 0.08-0.16 Hz) spreading downstream to all daughter arterioles. Systemic hypoxia caused an increase in vasomotion frequency of order 3 arterioles up to 0.3-0.5 Hz (average: 0.40 +/- 0.06 Hz) and a significant decrease in mean diameter(-28 +/- 5%). Phentolamine completely suppressed the rhythmic changes indiameter of order 3 arterioles that dilated significantly (+30 +/- 4%). Therefore, the effects of systemic hypoxia on arteriolar vasomotion appearto be triggered by an increase in sympathetic nervous discharge that induces a rise in frequency up to 0.3-0.5 Hz. (C) 2001 Elsevier Science B.V. Allrights reserved.

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Documento generato il 28/03/20 alle ore 10:50:53