Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Bimodal dose-dependent effect on autonomic, cardiac control after oral administration of Atropa belladonna
Autore:
Bettermann, H; Cysarz, D; Portsteffen, A; Kummell, HC;
Indirizzi:
Gemeinschaftskrankenhaus, Dept Clin Res, D-58313 Herdecke, Germany Gemeinschaftskrankenhaus Herdecke Germany D-58313 8313 Herdecke, Germany
Titolo Testata:
AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL
fascicolo: 1-2, volume: 90, anno: 2001,
pagine: 132 - 137
SICI:
1566-0702(20010720)90:1-2<132:BDEOAC>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACUTE MYOCARDIAL-INFARCTION; HEART-RATE FLUCTUATIONS; TRANSDERMAL SCOPOLAMINE; SPECTRAL-ANALYSIS; RATE-VARIABILITY; POWER SPECTRUM; VAGAL TONE; BAROREFLEX; SENSITIVITY; VOLUNTEERS;
Keywords:
heart rate variability; atropine; scopolamine; spectral analysis; herbal medicine; beat-to-beat blood pressure; barorefIex sensitivity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Bettermann, H Gemeinschaftskrankenhaus, Dept Clin Res, D-58313 Herdecke, Germany Gemeinschaftskrankenhaus Herdecke Germany D-58313 Germany
Citazione:
H. Bettermann et al., "Bimodal dose-dependent effect on autonomic, cardiac control after oral administration of Atropa belladonna", AUTON NEURO, 90(1-2), 2001, pp. 132-137

Abstract

This single-blind placebo-controlled study was designed to investigate thedose-dependent vagolytic and vagotonic effects after a single oral administration of Atropa belladonna tincture (ABT, 0.1 mg/ml alkaloid concentration, atropine/scopolamine = 20:1). In eight healthy young subjects, heart rate and noninvasive arterial finger blood pressure were recorded simultaneously over 4 h after oral application of four different doses of ABT (day 1: 2mi, day 2. placebo, day 3. 5 mi, day 4. 1 mi). On each day, 14 20-min sequences under controlled experimental conditions were performed. Among others, mean RR interval (RR), high-frequency spectral power of heart rate variability (HF), and noninvasive baroreflex sensitivity (BRS) were calculated during metronome breathing in supine position. These parameters were robust markers of vagal activity. One hour after 5ml ABT, RR, HF and BRS decreased clearly in six of eight subjects. This effect was interpreted as vagolytic response. After 1 and 2 mi ABT, and after placebo, RR and KF increased markedly. The increase after ABT was much higher than the increase solely due to adaptation after placebo administration, and it could be clearly identified as an augmentation of vagal cardiac activity caused by law-dose ABT. In conclusion, low doses of orally administered ABT can be effectively used tostimulate parasympathetic activity in man. The mode of vagal activation changes between 2 and 5 mi ABT from vagotonic to vagolytic. ABT has no or very Little effect on blood pressure control. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 22:15:15