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Titolo:
Fine alterations of distortion-product otoacoustic emissions after moderate acoustic overexposure in guinea pigs
Autore:
Kossowski, M; Mom, T; Guitton, M; Poncet, JL; Bonfils, P; Avan, P;
Indirizzi:
Univ Paris 05, Hop Europeen Georges Pompidou, Fac Necker Enfants Malad, Unite CNRS,UPRESA 7060, Paris, France Univ Paris 05 Paris France Malad, Unite CNRS,UPRESA 7060, Paris, France Univ Paris 05, Hop Europeen Georges Pompidou, Format Associee Claude Bernard, Lab Rech Audit, Paris, France Univ Paris 05 Paris France laude Bernard, Lab Rech Audit, Paris, France Hop Instruct Armees Val de Grace, Serv ORL Chirurg Cervicofaciale, Paris, France Hop Instruct Armees Val de Grace Paris France icofaciale, Paris, France Univ Auvergne, Fac Med Clermont Ferrand, Biophys Lab, Clermont Ferrand, France Univ Auvergne Clermont Ferrand France hys Lab, Clermont Ferrand, France
Titolo Testata:
AUDIOLOGY
fascicolo: 3, volume: 40, anno: 2001,
pagine: 113 - 122
SICI:
0020-6091(200105/06)40:3<113:FAODOE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
TEMPORARY THRESHOLD SHIFT; HAIR CELL LOSS; COCHLEAR MECHANICS; SOUND EXPOSURE; NOISE EXPOSURE; ACTIVE PROCESS; INNER-EAR; STEREOCILIA; RESPONSES; TRAUMA;
Keywords:
auditory fatigue; hearing loss; acoustic overexposure; distortion-product otoacoustic emissions;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Avan, P Sch Med, Dept Biophys, POB 38, F-63001 Clermont Ferrand, France Sch Med POB 38 Clermont Ferrand France F-63001 nt Ferrand, France
Citazione:
M. Kossowski et al., "Fine alterations of distortion-product otoacoustic emissions after moderate acoustic overexposure in guinea pigs", AUDIOLOGY, 40(3), 2001, pp. 113-122

Abstract

Guinea pigs were exposed to a pure tone at 6 kHz and 80 dB SPL for 30 minutes in order to induce mild reversible auditory fatigue over the 4 hours following exposure. Cochlear monitoring aimed to compare the shifts in round-window compound action potentials (CAP) thresholds to those of 2f1-f2 distortion-product otoacoustic emissions (DPOAE, frequency of stimuli f1 and f2). Both responses were evaluated every 1/10th octave between 6 and 12 kHz for CAP thresholds, and from 4 to about 14 kHz for DPOAEs in response to 50- and 70-dB SPL stimuli. The auditory fatigue turned out to be sufficiently mild that DPOAEs remained present, so that their microstructure could be followed up while the stimulus frequency ratio f2/f1 was swept from 1.06 to 1.30 (fixed f2) so as to derive DPOAE level profiles against f2/f1 and group latencies. CAP thresholds decreased by about 10 dB above 7.2 kHz, whereas DPOAE amplitudes decreased at most f2 frequencies from 6.6 kHz to 15.2 kH.z,with the range of decrease being slightly narrower at higher stimulus intensities. While the mean DPOAE shift after 1 hour was around 5 dB irrespective of stimulus intensity, it tended to increase slightly after 2 hours despite stable CAP thresholds. DPOAE profiles against f2/f1 were slightly modified by the auditory fatigue, so that the maximum tended to be reached at lower ratio. No significant variation of DPOAE latencies was found after acoustic overstimulation. These experiments show that complex DPOAE changes were induced by auditory fatigue and their relationship to CAP threshold changes does not seem to be straight-forward. Nonetheless, fine DPOAE recordingsmight be useful to detect early changes in cochlear mechanics.

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Documento generato il 04/12/20 alle ore 02:22:20