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Titolo:
Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus
Autore:
Frenais, R; Ouguerram, K; Maugeais, C; Mahot, P; Charbonnel, B; Magot, T; Krempf, M;
Indirizzi:
Hotel Dieu, Ctr Rech Nutr Humaine, Grp Metab, INSERM,U539, Nantes, France Hotel Dieu Nantes France umaine, Grp Metab, INSERM,U539, Nantes, France Hotel Dieu, Clin Endocrinol Malad Metab & Nutr, Nantes, France Hotel DieuNantes France Endocrinol Malad Metab & Nutr, Nantes, France
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 157, anno: 2001,
pagine: 131 - 135
SICI:
0021-9150(200107)157:1<131:EODOFA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRACTIONAL CATABOLIC RATE; FISH-OIL; CHOLESTEROL LEVELS; METABOLISM; NIDDM; HYPERTRIGLYCERIDEMIA;
Keywords:
n-3 polyunsaturated acids; HDL; apo AI; kinetic; type II diabetes mellitus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Krempf, M Hotel Dieu, Ctr Rech Nutr Humaine, Grp Metab, INSERM,U539, Nantes, France Hotel Dieu Nantes France p Metab, INSERM,U539, Nantes, France
Citazione:
R. Frenais et al., "Effect of dietary omega-3 fatty acids on high-density lipoprotein apolipoprotein AI kinetics in type II diabetes mellitus", ATHEROSCLER, 157(1), 2001, pp. 131-135

Abstract

The effect of a dietary fish oil supplementation on metabolism of HDL was studied in type II diabetes mellitus. Endogenous labeling of HDL-apo AI wasperformed using a 14 h primed infusion of D3-leucine in five diabetic patients before and 2 months after treatment with maxEPA(R). Isotopic enrichment curves were analyzed using a monoexponential function. After treatment, plasma cholesterol level remained unchanged (205.4 +/- 41.9 vs. 206.8 +/- 30.7 mg/dl, NS), whereas plasma triglycerides were decreased (155.4 +/- 67.9 vs. 202.6 +/- 32.2 mg.dl, P=0.06). Plasma apo AI was similar under maxEPA(R). (116.0 +/- 25.6 vs. 111.8 +/- 25.4 mg/dl, NS), and HDL-cholesterol and HDL-triglycerides were also not markedly changed (30.2 +/- 10.0 vs. 27.1 +/-10 mg/dl, and 15.3 +/-9.8 vs. 19.2 +/- 10.4 mg/dl, NS). HDL-apo AI fractional catabolic rate (FCR) and absolute production rate (APR) were significantly decreased after treatment with maxEPA(R) (0.27 +/-0.09 vs. 0.37 +/-0.08pool day, P < 0.05, and 12.1<plus/minus>2.8 vs. 16.1 +/- 3.3 mg/kg per day, P < 0.05). These findings showed an effect of maxEPA(R) on kinetics of apolipoprotein AI in type II diabetes mellitus, probably linked to changes inplasma triglyceride level. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 18/01/20 alle ore 21:46:50