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Titolo:
The apoAI-CIII-AIV gene cluster
Autore:
Groenendijk, M; Cantor, RM; de Bruin, TWA; Dallinga-Thie, GM;
Indirizzi:
Univ Utrecht, Dept Internal Med G02 228, Med Ctr, NL-3508 GA Utrecht, Netherlands Univ Utrecht Utrecht Netherlands NL-3508 GA 3508 GA Utrecht, Netherlands Univ Calif Los Angeles, Dept Human Genet, Los Angeles, CA USA Univ Calif Los Angeles Los Angeles CA USA man Genet, Los Angeles, CA USA Univ Hosp Maastricht, Dept Internal Med, Maastricht, Netherlands Univ HospMaastricht Maastricht Netherlands ed, Maastricht, Netherlands
Titolo Testata:
ATHEROSCLEROSIS
fascicolo: 1, volume: 157, anno: 2001,
pagine: 1 - 11
SICI:
0021-9150(200107)157:1<1:TAGC>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
APOLIPOPROTEIN-A-IV; FAMILIAL COMBINED HYPERLIPIDEMIA; C-III GENE; CORONARY-ARTERY DISEASE; TRIGLYCERIDE-RICH LIPOPROTEINS; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; BINDING CASSETTE TRANSPORTER-1; FRAGMENT-LENGTH-POLYMORPHISMS; INSULIN-RESPONSE ELEMENT; TYPE-2 DIABETIC-PATIENTS;
Keywords:
apolipoproteins A-I; A-IV; C-III; polymorphism; familial combined hyperlipidemia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
151
Recensione:
Indirizzi per estratti:
Indirizzo: Dallinga-Thie, GM Univ Utrecht, Dept Internal Med G02 228, Med Ctr, POB 85500, NL-3508 GA Utrecht, Netherlands Univ Utrecht POB 85500 Utrecht Netherlands NL-3508 GA s
Citazione:
M. Groenendijk et al., "The apoAI-CIII-AIV gene cluster", ATHEROSCLER, 157(1), 2001, pp. 1-11

Abstract

The relationship between variations in the apoAI-CIII-AIV gene cluster andplasma lipid traits has been recognized for at least 15 years. Most studies have been focused upon the association between plasma triglycerides and agenetic variation present in the 3' untranslated region of the apoC-III gene (SstI polymorphism). Although not all studies showed similar results, this variant is most consistently found in association with plasma triglycerides. The other most interesting DNA variant is the mutation present in the promoter region of the apo A-I gene at position -75 (Msp-AI polymorphism), which has been associated with differences in plasma apoA-I and HDL-cholesterol levels. In this review, we will discuss the most frequent occurring genetic variants in the apoAI-CIII-AIV gene cluster and their impact on plasma lipid traits and associations with increased risk on developing coronary artery disease. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 17:51:56