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Titolo:
Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia
Autore:
Xia, SJ; Xu, CX; Tang, XD; Wang, WZ; Du, DL;
Indirizzi:
Shanghai Univ, Peoples Hosp 1, Dept Urol, Shanghai 200080, Peoples R ChinaShanghai Univ Shanghai Peoples R China 200080 ai 200080, Peoples R China Shandong Provincial Hosp, Dept Urol, Jinan 250021, Peoples R China Shandong Provincial Hosp Jinan Peoples R China 250021 1, Peoples R China Shandong Provincial Hosp, Dept Pathol, Jinan 250021, Peoples R China Shandong Provincial Hosp Jinan Peoples R China 250021 1, Peoples R China
Titolo Testata:
ASIAN JOURNAL OF ANDROLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 131 - 134
SICI:
1008-682X(200106)3:2<131:AAHMID>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-DEATH; ANDROGEN; EPITHELIUM; ESTROGEN; STROMA;
Keywords:
prostate; ductal system; hormonal milieu; androgen; estrogen; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Xia, SJ Shanghai Univ, Peoples Hosp 1, Dept Urol, 85 Wu Jin Rd, Shanghai 200080, Peoples R China Shanghai Univ 85 Wu Jin Rd Shanghai Peoples R China200080 China
Citazione:
S.J. Xia et al., "Apoptosis and hormonal milieu in ductal system of normal prostate and benign prostatic hyperplasia", ASIAN J AND, 3(2), 2001, pp. 131-134

Abstract

Aim: To study the apoptotic rate (AR) and the androgen and estrogen milieuin the proximal and distal ductal systems of prostate, in order to help exploring the effects of these factors on prostatic growth and the pathogenesis of benign prostatic hypertrophy (BPH). Methods: The proximal and distal ends of the ductal system were incised from 20 normal prostate as well as the hypertrophic prostate tissue from 20 patients with BPH. The AR was determined by the DNA end-labeling method and dihydrotestosterone (DHT) and estrodiol (E-2), by radioimmunoassay. Results: There was no significant difference in DHT and E-2 density between the proximal and distal ends of the ductal systems in normal prostate. E-2 appeared to be higher in BPH than in normal prostatic tissues, but the difference was statistically insignificant. In normal prostatic tissue, the AR was significantly higher in the distal than in the proximal ends of the ductal system (P < 0.05), while the AR of the proximal ends was significantly higher (P < 0.01) than that in the BPH tissue. No significant correlation was noted between the DHT and E-2 densityand the AR both in the normal prostate and BPH tissues. Conclusion: The paper is the first time describing a difference in AR in different regions ofthe ductal system of normal prostate, while the hormonal milieu is similar, indicating a functional inhomogeneity of these regions. A low AR in the proximal duct, where BPH originates, and an even lower AR in the BPH tissue,sug gesting the participation of apoptosis in the BPH pathogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 11:57:59