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Titolo:
Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats
Autore:
Izawa, M; Kimura, M; Yamada, T; Saji, M;
Indirizzi:
Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan Tottori Univ, Fac Med, Sch Life Sci, Dept Neurobiol, Yonago, Tottori 6838503, Japan Tottori Univ Yonago Tottori Japan 6838503 Yonago, Tottori 6838503, Japan
Titolo Testata:
ASIAN JOURNAL OF ANDROLOGY
fascicolo: 2, volume: 3, anno: 2001,
pagine: 105 - 108
SICI:
1008-682X(200106)3:2<105:CEOCIE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERLEUKIN-1-BETA CONVERTING-ENZYME; MOLECULAR-CLONING; APOPTOSIS; GENE; PROTEASE; DEATH;
Keywords:
prostate; seminal vesicles; tissue involution; apoptosis; caspase-1; cDNA; cloning; castration; epithelium; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Izawa, M Tottori Univ, Fac Med, Sch Life Sci, Dept Biosignaling, 86 Nishi Machi, Yonago, Tottori 6838503, Japan Tottori Univ 86 Nishi Machi Yonago Tottori Japan 6838503 3, Japan
Citazione:
M. Izawa et al., "Castration-induced expression of caspase-1 in epithelia of accessory sex organs in male rats", ASIAN J AND, 3(2), 2001, pp. 105-108

Abstract

Aim: As an attempt to clarify the molecular basis of castration-induced apoptosis, this study was undertaken to demonstrate the expression of caspase-1 in male accessory sex organs of rats. Methods and results: cDNA of rat caspase-1 was cloned by reverse transcription-polymerase chain reaction fromthe ventral prostates. The open reading frame predicts 402 amino acids, which shows more than 91% and 63% identity to those of mouse and human, respectively. Northern analyses demonstrated the presence of castration-induced up-regulation of the 1.6 kb transcript in the ventral prostate and the seminal vesicles. Finally, the authors demonstrated the caspase-1 transcripts in the epithelia of these tissues by in situ hybridization analyses. Conclusion: Castration induces the expression of caspase-1 transcripts in the epithelia of ventral prostate and seminal vesicle. These observations suggest apossible role of caspase-1 in apoptosis in male accessory sex organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 22:33:58